AT-9283 is a small-molecule multi-targeted kinase inhibitor with potent bioactivity against Aurora A and B kinases, JAK2, JAK3, and Abl kinases. It exhibits IC₅₀ values of 3 nM for Aurora B, 21 nM for Aurora A, 1.2 nM for JAK2, 1.1 nM for JAK3, and approximately 3 nM for Abl (including the T315I mutant). In preclinical cancer models, AT-9283 induces polyploidy and apoptosis in tumor cells due to mitotic disruption from Aurora inhibition, and demonstrates antiproliferative effects across a range of hematologic malignancies and solid tumors. It has shown in vivo efficacy in xenograft models and entered early-phase clinical trials, though dose-limiting toxicities such as neutropenia were observed.
MedKoo Cat#: 529102
Name: AT-9283 HCl
CAS#: 896466-61-8 (HCl)
Chemical Formula: C19H24ClN7O2
Exact Mass: 0.0000
Molecular Weight: 417.89
Elemental Analysis: Chemical Formula: C19H24ClN7O2 Exact Mass: 417.1680 Molecular Weight: 417.8980 Elemental Analysis: C, 54.61; H, 5.79; Cl, 8.48; N, 23.46; O, 7.66
The following data is based on the product molecular weight 417.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
