OPC-51803 | CAS#192514-54-8 | vasopressin V2 receptor agonist

MedKoo Cat#: 529327 | Name: OPC-51803

Description:

WARNING: This product is for research use only, not for human or veterinary use.

OPC-51803 is a vasopressin V2 receptor agonist potentially for the treatment of incontinence and nocturia.

Chemical Structure

OPC-51803

CAS#192514-54-8

Theoretical Analysis

MedKoo Cat#: 529327

Name: OPC-51803

CAS#: 192514-54-8

Chemical Formula: C26H32ClN3O2

Exact Mass: 453.2183

Molecular Weight: 454.01

Elemental Analysis: C, 68.78; H, 7.10; Cl, 7.81; N, 9.26; O, 7.05

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

OPC-51803; SOU-003; OPC51803; SOU003; OPC 51803; SOU 003

IUPAC/Chemical Name

1H-1-Benzazepine-5-acetamide, 1-(2-chloro-4-(1-pyrrolidinyl)benzoyl)-2,3,4,5-tetrahydro-N-(1-methylethyl)-, (R)-

InChi Key

INGXCNVWWKKWOO-LJQANCHMSA-N

InChi Code

InChI=1S/C26H32ClN3O2/c1-18(2)28-25(31)16-19-8-7-15-30(24-10-4-3-9-21(19)24)26(32)22-12-11-20(17-23(22)27)29-13-5-6-14-29/h3-4,9-12,17-19H,5-8,13-16H2,1-2H3,(H,28,31)/t19-/m1/s1

SMILES Code

O=C(NC(C)C)C[C@H]1CCCN(C(C2=CC=C(N3CCCC3)C=C2Cl)=O)C4=CC=CC=C14

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 454.01 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Nakamura S, Hirano T, Tsujimae K, Aoyama M, Kondo K, Yamamura Y, Mori T, Tominaga M. Antidiuretic effects of a nonpeptide vasopressin V(2)-receptor agonist, OPC-51803, administered orally to rats. J Pharmacol Exp Ther. 2000 Dec;295(3):1005-11. PubMed PMID: 11082435. 2: Nakamura S, Hirano T, Yamamura Y, Itoh S, Kondo K, Mori T, Kambe T. Effects of OPC-51803, a novel, nonpeptide vasopressin V2-receptor agonist, on micturition frequency in Brattleboro and aged rats. J Pharmacol Sci. 2003 Dec;93(4):484-8. PubMed PMID: 14737021. 3: Mishra S, Liu J, Aponick A. Enantioselective Alkyne Conjugate Addition Enabled by Readily Tuned Atropisomeric P,N-Ligands. J Am Chem Soc. 2017 Feb 21. doi: 10.1021/jacs.7b00363. [Epub ahead of print] PubMed PMID: 28207253. 4: Nakamura S, Hirano T, Onogawa T, Itoh S, Hashimoto A, Yamamura Y, Kondo K, Mori T, Kambe T. Antidiuretic effects of a novel nonpeptide vasopressin V(2)-receptor agonist, OPC-51803, administered orally to dogs. J Pharmacol Sci. 2004 Apr;94(4):426-33. PubMed PMID: 15107583. 5: Nakamura S, Yamamura Y, Itoh S, Hirano T, Tsujimae K, Aoyama M, Kondo K, Ogawa H, Shinohara T, Kan K, Tanada Y, Teramoto S, Sumida T, Nakayama S, Sekiguchi K, Kambe T, Tsujimoto G, Mori T, Tominaga M. Characterization of a novel nonpeptide vasopressin V(2)-agonist, OPC-51803, in cells transfected human vasopressin receptor subtypes. Br J Pharmacol. 2000 Apr;129(8):1700-6. PubMed PMID: 10780976; PubMed Central PMCID: PMC1571993. 6: Bayes M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2003 Jun;25(5):387-408. PubMed PMID: 12851663. 7: Tsujimoto G, Takano Y. New topics in vasopressin receptors and approach to novel drugs: preface. J Pharmacol Sci. 2009 Jan;109(1):32. PubMed PMID: 19151538. 8: Pitt GR, Batt AR, Haigh RM, Penson AM, Robson PA, Rooker DP, Tartar AL, Trim JE, Yea CM, Roe MB. Non-peptide oxytocin agonists. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4585-9. PubMed PMID: 15357997.