HT1042 | CAS# 23589-77-7

MedKoo Cat#: 531955 | Name: HT1042

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HT1042 inhibits the β5i component of the 20S proteasome complex, used to aid in the treatment of autoimmune and inflammatory diseases and hematologic malignancies.

Chemical Structure

HT1042

CAS#23589-77-7

Theoretical Analysis

MedKoo Cat#: 531955

Name: HT1042

CAS#: 23589-77-7

Chemical Formula: C8H4N2O4S

Exact Mass: 223.9892

Molecular Weight: 224.19

Elemental Analysis: C, 42.86; H, 1.80; N, 12.50; O, 28.55; S, 14.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

HT1042; HT 1042; HT-1042.

IUPAC/Chemical Name

5-(3-nitrophenyl)-1,3,4-oxathiazol-2-one

InChi Key

QBAZATRGWRVUFN-UHFFFAOYSA-N

InChi Code

InChI=1S/C8H4N2O4S/c11-8-14-7(9-15-8)5-2-1-3-6(4-5)10(12)13/h1-4H

SMILES Code

O=C1OC(C2=CC=CC([N+]([O-])=O)=C2)=NS1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 224.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Fan H, Angelo NG, Warren JD, Nathan CF, Lin G. Oxathiazolones Selectively Inhibit the Human Immunoproteasome over the Constitutive Proteasome. ACS Med Chem Lett. 2014 Feb 3;5(4):405-10. doi: 10.1021/ml400531d. PubMed PMID: 24900849; PubMed Central PMCID: PMC4027612.