GW9578 | CAS# 247923-29-1| PPARα Agonist

MedKoo Cat#: 531943 | Name: GW9578

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GW 9578 is a potent agonist of PPARα that activates the murine and human receptors with EC50 values of 0.005 and 0.05 µM. GW 9578 is a potent lipid lowering agent that may reduce insulin resistance.

Chemical Structure

GW9578

CAS#247923-29-1

Theoretical Analysis

MedKoo Cat#: 531943

Name: GW9578

CAS#: 247923-29-1

Chemical Formula: C26H34F2N2O3S

Exact Mass: 492.2258

Molecular Weight: 492.63

Elemental Analysis: C, 63.39; H, 6.96; F, 7.71; N, 5.69; O, 9.74; S, 6.51

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 485.00	2 Weeks
10mg	USD 850.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

GW9578; GW 9578; GW-9578

IUPAC/Chemical Name

2-[4-[2-[(2,4-difluorophenyl)carbamoyl-heptylamino]ethyl]phenyl]sulfanyl-2-methylpropanoic acid

InChi Key

KYQNYMXQHLMADB-UHFFFAOYSA-N

InChi Code

InChI=1S/C26H34F2N2O3S/c1-4-5-6-7-8-16-30(25(33)29-23-14-11-20(27)18-22(23)28)17-15-19-9-12-21(13-10-19)34-26(2,3)24(31)32/h9-14,18H,4-8,15-17H2,1-3H3,(H,29,33)(H,31,32)

SMILES Code

CC(C)(SC1=CC=C(CCN(C(NC2=CC=C(F)C=C2F)=O)CCCCCCC)C=C1)C(O)=O

Appearance

A solution in methyl acetate

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

GW9578 is a subtype-selective PPARα agonist (EC50s of 5 and 50 nM for murine and human PPAR-α) with potent lipid-lowering activity.

In vitro activity:

PPARα ligand GW9578 downregulated TgMPO-G in GMCSF-Mφ, while upregulating in MCSF-Mφ (lanes 4). Reference: Biochem Biophys Res Commun. 2006 Oct 20;349(2):846-54. https://pubmed.ncbi.nlm.nih.gov/16956579/

In vivo activity:

Treatment with GW9578 resulted in markedly reduced serum insulin concentrations, whereas serum glucose levels were not affected (Fig. 6). Thus, as with ciprofibrate, treatment with GW9578 resulted in efficient PPARα activation, whereas PPARγ was not activated in these rats. Reference: J Biol Chem. 2000 Jun 2;275(22):16638-42. https://pubmed.ncbi.nlm.nih.gov/10828060/

	Solvent	mg/mL	mM
Solubility
	DMF	10.0	20.30
	DMSO	10.0	20.30
	DMSO:PBS (pH 7.2) (1:2)	0.3	0.61
	Ethanol	2.5	5.07

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 492.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Reynolds WF, Kumar AP, Piedrafita FJ. The human myeloperoxidase gene is regulated by LXR and PPARalpha ligands. Biochem Biophys Res Commun. 2006 Oct 20;349(2):846-54. doi: 10.1016/j.bbrc.2006.08.119. Epub 2006 Aug 31. PMID: 16956579; PMCID: PMC1831877. 2. Guerre-Millo M, Gervois P, Raspé E, Madsen L, Poulain P, Derudas B, Herbert JM, Winegar DA, Willson TM, Fruchart JC, Berge RK, Staels B. Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. J Biol Chem. 2000 Jun 2;275(22):16638-42. doi: 10.1074/jbc.275.22.16638. PMID: 10828060.

In vitro protocol:

In vivo protocol:

1. Guerre-Millo M, Gervois P, Raspé E, Madsen L, Poulain P, Derudas B, Herbert JM, Winegar DA, Willson TM, Fruchart JC, Berge RK, Staels B. Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. J Biol Chem. 2000 Jun 2;275(22):16638-42. doi: 10.1074/jbc.275.22.16638. PMID: 10828060.

1: Brown PJ, Winegar DA, Plunket KD, Moore LB, Lewis MC, Wilson JG, Sundseth SS, Koble CS, Wu Z, Chapman JM, Lehmann JM, Kliewer SA, Willson TM. A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity. J Med Chem. 1999 Sep 23;42(19):3785-8. PubMed PMID: 10508427.