Sinogliatin | HMS-5552 | RO-5305552 |CAS#1191996-10-7 | glucokinase activator

MedKoo Cat#: 529313 | Name: Sinogliatin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sinogliatin, also known as HMS-5552 isomer and RO-5305552, isomer, is a glucokinase activator potentially for the treatment of type 2 diabetes. Sinogliatin is a S-isomer of Dorzagliatin. Sinogliatin has SS-configuration, and Dorzagliatin has SR-configuration.

Chemical Structure

Sinogliatin

CAS#1191996-10-7

Theoretical Analysis

MedKoo Cat#: 529313

Name: Sinogliatin

CAS#: 1191996-10-7

Chemical Formula: C22H27ClN4O5

Exact Mass: 462.1670

Molecular Weight: 462.93

Elemental Analysis: C, 57.08; H, 5.88; Cl, 7.66; N, 12.10; O, 17.28

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

HMS-5552 isomer; RO-5305552; HMS5552; RO5305552 isomer; HMS 5552; RO 5305552; Sinogliatin; Dorzagliatin-isomer

IUPAC/Chemical Name

(S)-2-(4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(1-((S)-2,3-dihydroxypropyl)-1H-pyrazol-3-yl)-4-methylpentanamide

InChi Key

HMUMWSORCUWQJO-YJBOKZPZSA-N

InChi Code

InChI=1S/C22H27ClN4O5/c1-14(2)9-18(22(31)24-20-7-8-26(25-20)11-15(29)13-28)27-12-16(10-21(27)30)32-19-6-4-3-5-17(19)23/h3-8,10,14-15,18,28-29H,9,11-13H2,1-2H3,(H,24,25,31)/t15-,18-/m0/s1

SMILES Code

CC(C)C[C@H](N1CC(OC2=CC=CC=C2Cl)=CC1=O)C(NC3=NN(C[C@H](O)CO)C=C3)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 462.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Liu D, Zhang Y, Jiang J, Choi J, Li X, Zhu D, Xiao D, Ding Y, Fan H, Chen L, Hu P. Translational Modeling and Simulation in Supporting Early-Phase Clinical Development of New Drug: A Learn-Research-Confirm Process. Clin Pharmacokinet. 2016 Dec 20. doi: 10.1007/s40262-016-0484-2. [Epub ahead of print] PubMed PMID: 28000102.