GV196771A | CAS#166974-22-7 |NMDA Antagonist

MedKoo Cat#: 531887 | Name: GV196771A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GV196771A is an NMDA receptor/glycine site antagonist. GV196771A attenuates mechanical allodynia in neuropathic rats and reduces tolerance induced by morphine in mice.

Chemical Structure

GV196771A

CAS#166974-22-7

Theoretical Analysis

MedKoo Cat#: 531887

Name: GV196771A

CAS#: 166974-22-7

Chemical Formula: C20H13Cl2N2O3-

Exact Mass: 399.0309

Molecular Weight: 400.24

Elemental Analysis: C, 60.02; H, 3.27; Cl, 17.71; N, 7.00; O, 11.99

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

GV196771A; GV 196771A; GV-196771A.

IUPAC/Chemical Name

4,6-dichloro-3-{[(3E)-2-oxo-1-phenylpyrrolidin-3-ylidene]methyl}-1H-indole-2-carboxylate

InChi Key

VDIRQCDDCGAGET-DHZHZOJOSA-M

InChi Code

InChI=1S/C20H14Cl2N2O3/c21-12-9-15(22)17-14(18(20(26)27)23-16(17)10-12)8-11-6-7-24(19(11)25)13-4-2-1-3-5-13/h1-5,8-10,23H,6-7H2,(H,26,27)/p-1/b11-8+

SMILES Code

O=C(C(N1)=C(/C=C2C(N(C3=CC=CC=C3)CC/2)=O)C4=C1C=C(Cl)C=C4Cl)[O-]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 400.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Polli JW, Baughman TM, Humphreys JE, Jordan KH, Mote AL, Webster LO, Barnaby RJ, Vitulli G, Bertolotti L, Read KD, Serabjit-Singh CJ. The systemic exposure of an N-methyl-D-aspartate receptor antagonist is limited in mice by the P-glycoprotein and breast cancer resistance protein efflux transporters. Drug Metab Dispos. 2004 Jul;32(7):722-6. PubMed PMID: 15205387. 2: Quartaroli M, Fasdelli N, Bettelini L, Maraia G, Corsi M. GV196771A, an NMDA receptor/glycine site antagonist, attenuates mechanical allodynia in neuropathic rats and reduces tolerance induced by morphine in mice. Eur J Pharmacol. 2001 Nov 2;430(2-3):219-27. PubMed PMID: 11711034.