MedKoo Cat#: 464191 | Name: Tubermycin B
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tubermycin B is a bacterial metabolite that has been found in Pseudomonas and has antifungal and fungicidal activities. It is active against A. flavus, C. albicans, and T. rubrum, as well as the plant pathogenic fungi F. oxysporum and R. solani. Tubermycin B (10-500 µg/ml) prevents the development of foliar anthracnose lesions in cucumber plants infected with the plant pathogenic fungus C. orbiculare. Formulations containing tubermycin B have been used as fungicides in agriculture.

Chemical Structure

Tubermycin B
Tubermycin B
CAS#2538-68-3

Theoretical Analysis

MedKoo Cat#: 464191

Name: Tubermycin B

CAS#: 2538-68-3

Chemical Formula: C13H8N2O2

Exact Mass: 224.0586

Molecular Weight: 224.22

Elemental Analysis: C, 69.64; H, 3.60; N, 12.49; O, 14.27

Price and Availability

Size Price Availability Quantity
5mg USD 550.00 2 Weeks
10mg USD 950.00 2 Weeks
25mg USD 1,650.00 2 Weeks
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Related CAS #
No Data
Synonym
Tubermycin B; Tubermycin-B; NSC 15851; NSC15851; NSC-15851; PCA; Phenazine-1-carboxylate; Phenazinecarboxylic Acid; Phenazinecarboxylic-Acid; Shenqinmycin;
IUPAC/Chemical Name
phenazine-1-carboxylic acid
InChi Key
JGCSKOVQDXEQHI-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H8N2O2/c16-13(17)8-4-3-7-11-12(8)15-10-6-2-1-5-9(10)14-11/h1-7H,(H,16,17)
SMILES Code
O=C(O)C1=C2N=C3C=CC=CC3=NC2=CC=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
to be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
To be determined 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 224.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Binshaya AS, Alghamdi SA, Alharthi NS, Hjazi A, Alqasem AA, Almasoudi HH, Aldakheel FM, Fallatah D, Almoammar NE, Aloraini GS, Aloahd MS. Tubermycin B coated on Galactosylated Chitosan Nanoparticles synthesized by eco-friendly method ameliorates intracellular free radical production and reduces oxidative stress, reducing phosphorylation of IKKα/β/pIкBα/NF-кB pathway. Eur Rev Med Pharmacol Sci. 2023 Oct;27(19):9375-9387. doi: 10.26355/eurrev_202310_33965. PMID: 37843350. 2: S Hifnawy M, Hassan HM, Mohammed R, M Fouda M, Sayed AM, A Hamed A, F AbouZid S, Rateb ME, Alhadrami HA, Abdelmohsen UR. Induction of Antibacterial Metabolites by Co-Cultivation of Two Red-Sea-Sponge-Associated Actinomycetes Micromonospora sp. UR56 and Actinokinespora sp. EG49. Mar Drugs. 2020 May 5;18(5):243. doi: 10.3390/md18050243. PMID: 32380771; PMCID: PMC7281614. 3: Sarmin NIM, Tan GYA, Franco CMM, Edrada-Ebel R, Latip J, Zin NM. Streptomyces kebangsaanensis sp. nov., an endophytic actinomycete isolated from an ethnomedicinal plant, which produces phenazine-1-carboxylic acid. Int J Syst Evol Microbiol. 2013 Oct;63(Pt 10):3733-3738. doi: 10.1099/ijs.0.047878-0. Epub 2013 May 3. PMID: 23645019. 4: Gebhardt K, Schimana J, Krastel P, Dettner K, Rheinheimer J, Zeeck A, Fiedler HP. Endophenazines A-D, new phenazine antibiotics from the arthropod associated endosymbiont Streptomyces anulatus. I. Taxonomy, fermentation, isolation and biological activities. J Antibiot (Tokyo). 2002 Sep;55(9):794-800. doi: 10.7164/antibiotics.55.794. PMID: 12458768. 5: Keudell KC, Huang JK, Wen L, Klopfenstein WE, Bagby MO, Lanser AC, Plattner RD, Peterson RE, Weisleder D. Fatty acids enhanced tubermycin production by Pseudomonas strain 2HS. Microbios. 2000;102(401):27-38. PMID: 10817518. 6: Geiger A, Keller-Schierlein W, Brandl M, Zähner H. Metabolites of microorganisms. 247. Phenazines from Streptomyces antibioticus, strain Tü 2706. J Antibiot (Tokyo). 1988 Nov;41(11):1542-51. doi: 10.7164/antibiotics.41.1542. PMID: 3058669.