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MedKoo Cat#: 527720 | Name: ACP-0052

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ACP-0052, also known as SL-052 and ACP-SL-052, is a hypocrellin-based photosensitizer potentially for the treatment of prostate cancer.

Chemical Structure

ACP-0052
ACP-0052
CAS#925438-34-2

Theoretical Analysis

MedKoo Cat#: 527720

Name: ACP-0052

CAS#: 925438-34-2

Chemical Formula: C35H32N2O7

Exact Mass: 592.2210

Molecular Weight: 592.65

Elemental Analysis: C, 70.93; H, 5.44; N, 4.73; O, 18.90

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
ACP-0052; ACP 0052; ACP0052; SL-052; SL052; SL 052; ACP-SL-052; ACP SL 052; ACPSL052
IUPAC/Chemical Name
17-acetyl-2-hydroxy-1,5,6-trimethoxy-16-methyl-9a,10,11,12,13,13a,14,17-octahydro-3H-cyclohepta[12,1]peryleno[2,3-b]quinoxaline-3,8(9H)-dione
InChi Key
BSDCXVHKKRVTFB-UHFFFAOYSA-N
InChi Code
InChI=1S/C35H32N2O7/c1-13-10-15-23-28-24(33-32(15)36-16-8-6-7-9-17(16)37-33)18(39)11-20(42-3)26(28)27-21(43-4)12-19(40)25-30(27)29(23)31(22(13)14(2)38)35(44-5)34(25)41/h10-12,16-17,22,36-37,41H,6-9H2,1-5H3
SMILES Code
O=C(C1=C(O)C(OC)=C2C(C(C)=O)C(C)=C3)C=C(OC)C4=C1C2=C5C3=C6NC7CCCCC7NC6=C8C(C=C(OC)C4=C58)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 592.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Korbelik M, Madiyalakan R, Woo T, Haddadi A. Antitumor efficacy of photodynamic therapy using novel nanoformulations of hypocrellin photosensitizer SL052. Photochem Photobiol. 2012 Jan-Feb;88(1):188-93. doi: 10.1111/j.1751-1097.2011.01035.x. PubMed PMID: 22070614. 2: Meng Y, Zou C, Madiyalakan R, Woo T, Huang M, Yang X, Swanson E, Chen J, Xing JZ. Water-soluble and biocompatible sono/photosensitizer nanoparticles for enhanced cancer therapy. Nanomedicine (Lond). 2010 Dec;5(10):1559-69. doi: 10.2217/nnm.10.91. PubMed PMID: 21143033. 3: Xiao Z, Owen RJ, Liu W, Tulip J, Brown K, Woo T, Moore RB. Lipophilic photosensitizer administration via the prostate arteries for photodynamic therapy of the canine prostate. Photodiagnosis Photodyn Ther. 2010 Jun;7(2):106-14. doi: 10.1016/j.pdpdt.2010.03.003. PubMed PMID: 20510305.