MedKoo Cat#: 530307 | Name: LY2881835

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY2881835 is a potent and selective GPR40 agonist potentially for treatment of type 2 diabetes mellitus. The free fatty acid receptor 1 (FFA1), a G protein-coupled receptor (GPCR) naturally activated by long-chain fatty acids is a novel target for the treatment of metabolic diseases.

Chemical Structure

LY2881835
LY2881835
CAS#1292290-38-0

Theoretical Analysis

MedKoo Cat#: 530307

Name: LY2881835

CAS#: 1292290-38-0

Chemical Formula: C33H35NO3

Exact Mass: 493.2617

Molecular Weight: 493.65

Elemental Analysis: C, 80.29; H, 7.15; N, 2.84; O, 9.72

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
LY2881835; LY-2881835; LY 2881835.
IUPAC/Chemical Name
(S)-3-(4-((4-((2,3-dihydrospiro[indene-1,4'-piperidin]-1'-yl)methyl)benzyl)oxy)phenyl)hex-4-ynoic acid
InChi Key
WKVVLTUTCPYXBP-LJAQVGFWSA-N
InChi Code
InChI=1S/C33H35NO3/c1-2-5-29(22-32(35)36)27-12-14-30(15-13-27)37-24-26-10-8-25(9-11-26)23-34-20-18-33(19-21-34)17-16-28-6-3-4-7-31(28)33/h3-4,6-15,29H,16-24H2,1H3,(H,35,36)/t29-/m0/s1
SMILES Code
O=C(O)C[C@H](C#CC)C(C=C1)=CC=C1OCC(C=C2)=CC=C2CN(CC3)CCC3(CC4)C5=C4C=CC=C5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 493.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Krasavin M, Lukin A, Bagnyukova D, Zhurilo N, Zahanich I, Zozulya S. Novel FFA1 (GPR40) agonists containing spirocyclic periphery: polar azine periphery as a driver of potency. J Enzyme Inhib Med Chem. 2016 Oct 26:1-8. [Epub ahead of print] PubMed PMID: 27781494. 2: Hamdouchi C, Kahl SD, Patel Lewis A, Cardona GR, Zink RW, Chen K, Eessalu TE, Ficorilli JV, Marcelo MC, Otto KA, Wilbur KL, Lineswala JP, Piper JL, Coffey DS, Sweetana SA, Haas JV, Brooks DA, Pratt EJ, Belin RM, Deeg MA, Ma X, Cannady EA, Johnson JT, Yumibe NP, Chen Q, Maiti P, Montrose-Rafizadeh C, Chen Y, Reifel Miller A. The Discovery, Preclinical and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083 and LY2922470). J Med Chem. 2016 Oct 17. [Epub ahead of print] PubMed PMID: 27749056. 3: Krasavin M, Lukin A, Bagnyukova D, Zhurilo N, Zahanich I, Zozulya S, Ihalainen J, Forsberg MM, Lehtonen M, Rautio J, Moore D, Tikhonova IG. Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835. Bioorg Med Chem. 2016 Nov 1;24(21):5481-5494. doi: 10.1016/j.bmc.2016.09.004. PubMed PMID: 27647366.