GLPG0974 is a selective GPR43 (FFAR2) antagonist developed to modulate short-chain fatty acid (SCFA) signaling in inflammatory diseases. It inhibits neutrophil chemotaxis and pro-inflammatory cytokine release, demonstrating potential in treating inflammatory bowel disease (IBD). Preclinical studies show nanomolar potency (IC₅₀ ~10–100 nM), reducing gut inflammation by blocking SCFA-induced immune activation.
MedKoo Cat#: 531847
Name: GLPG0974
CAS#: 1391076-61-1
Chemical Formula: C25H25ClN2O4S
Exact Mass: 484.1224
Molecular Weight: 484.99
Elemental Analysis: C, 61.91; H, 5.20; Cl, 7.31; N, 5.78; O, 13.20; S, 6.61
The following data is based on the product molecular weight 484.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |