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MedKoo Cat#: 529424 | Name: Phosphostim Sodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Phosphostim, also known as IPH-1101, is a gamma9deta2 T lymphocytes agonist potentially for the treatment of renal cell carcinoma, HCV infection.

Chemical Structure

Phosphostim Sodium
Phosphostim Sodium
CAS#259793-78-7 (sodium)

Theoretical Analysis

MedKoo Cat#: 529424

Name: Phosphostim Sodium

CAS#: 259793-78-7 (sodium)

Chemical Formula: C5H10BrNa3O8P2

Exact Mass:

Molecular Weight: 408.95

Elemental Analysis: C, 14.69; H, 2.46; Br, 19.54; Na, 16.87; O, 31.30; P, 15.15

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
303102-05-8 (free) 259793-78-7 (sodium)
Synonym
IPH-1101; IPH 1101; IPH1101; Phosphostim; Phosphostim Sodium
IUPAC/Chemical Name
sodium 4-bromo-3-hydroxy-3-methylbutyl diphosphate
InChi Key
GEPIOVCKTFYBAA-UHFFFAOYSA-K
InChi Code
InChI=1S/C5H13BrO8P2.3Na/c1-5(7,4-6)2-3-13-16(11,12)14-15(8,9)10;;;/h7H,2-4H2,1H3,(H,11,12)(H2,8,9,10);;;/q;3*+1/p-3
SMILES Code
OC(CCOP(OP(O[Na])(O[Na])=O)(O[Na])=O)(C)CBr
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 408.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Burjanadzé M, Condomines M, Reme T, Quittet P, Latry P, Lugagne C, Romagne F, Morel Y, Rossi JF, Klein B, Lu ZY. In vitro expansion of gamma delta T cells with anti-myeloma cell activity by Phosphostim and IL-2 in patients with multiple myeloma. Br J Haematol. 2007 Oct;139(2):206-16. PubMed PMID: 17897296. 2: Viey E, Fromont G, Escudier B, Morel Y, Da Rocha S, Chouaib S, Caignard A. Phosphostim-activated gamma delta T cells kill autologous metastatic renal cell carcinoma. J Immunol. 2005 Feb 1;174(3):1338-47. PubMed PMID: 15661891. 3: Wouters J, Yin F, Song Y, Zhang Y, Oudjama Y, Stalon V, Droogmans L, Morita CT, Oldfield E. A crystallographic investigation of phosphoantigen binding to isopentenyl pyrophosphate/dimethylallyl pyrophosphate isomerase. J Am Chem Soc. 2005 Jan 19;127(2):536-7. PubMed PMID: 15643873. 4: Braza MS, Klein B, Fiol G, Rossi JF. γδ T-cell killing of primary follicular lymphoma cells is dramatically potentiated by GA101, a type II glycoengineered anti-CD20 monoclonal antibody. Haematologica. 2011 Mar;96(3):400-7. doi: 10.3324/haematol.2010.029520. PubMed PMID: 21109686; PubMed Central PMCID: PMC3046271. 5: Braza MS, Caraux A, Rousset T, Lafaye de Micheaux S, Sicard H, Squiban P, Costes V, Klein B, Rossi JF. gammadelta T lymphocytes count is normal and expandable in peripheral blood of patients with follicular lymphoma, whereas it is decreased in tumor lymph nodes compared with inflammatory lymph nodes. J Immunol. 2010 Jan 1;184(1):134-40. doi: 10.4049/jimmunol.0901980. PubMed PMID: 19949101. 6: Bennouna J, Bompas E, Neidhardt EM, Rolland F, Philip I, Galéa C, Salot S, Saiagh S, Audrain M, Rimbert M, Lafaye-de Micheaux S, Tiollier J, Négrier S. Phase-I study of Innacell gammadelta, an autologous cell-therapy product highly enriched in gamma9delta2 T lymphocytes, in combination with IL-2, in patients with metastatic renal cell carcinoma. Cancer Immunol Immunother. 2008 Nov;57(11):1599-609. doi: 10.1007/s00262-008-0491-8. PubMed PMID: 18301889. 7: Bayes M. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2007 Mar;29(2):153-73. PubMed PMID: 17440629. 8: Sicard H, Ingoure S, Luciani B, Serraz C, Fournié JJ, Bonneville M, Tiollier J, Romagné F. In vivo immunomanipulation of V gamma 9V delta 2 T cells with a synthetic phosphoantigen in a preclinical nonhuman primate model. J Immunol. 2005 Oct 15;175(8):5471-80. PubMed PMID: 16210655. 9: Agrati C, Alonzi T, De Santis R, Castilletti C, Abbate I, Capobianchi MR, D'Offizi G, Siepi F, Fimia GM, Tripodi M, Poccia F. Activation of Vgamma9Vdelta2 T cells by non-peptidic antigens induces the inhibition of subgenomic HCV replication. Int Immunol. 2006 Jan;18(1):11-8. PubMed PMID: 16361319. 10: Song Y, Zhang Y, Wang H, Raker AM, Sanders JM, Broderick E, Clark A, Morita CT, Oldfield E. Synthesis of chiral phosphoantigens and their activity in gamma delta T cell stimulation. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4471-7. PubMed PMID: 15357974.