Synonym
SHR-110008; SHR110008; SHR 110008; Felotaxel
IUPAC/Chemical Name
(2aS,2bR,3S,4S,11bS)-10-((2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)methyl)-2a-acetoxy-6-((3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-4,12-dihydroxy-7,11b,14,14-tetramethyl-2a,2b,3,4,5,6,8a,11a,11b,12,13,13a-dodecahydro-2H-4,8-methanooxeto[3'',2'':3',4']benzo[1',2':3,4]cyclodeca[1,2-d][1,3]dioxol-3-yl benzoate
InChi Key
GZMARNNFOHRGHP-UJHVPACVSA-N
InChi Code
InChI=1S/C50H64N2O15/c1-26-32(62-44(57)38(55)37(28-15-11-9-12-16-28)51-45(58)67-46(3,4)5)21-50(59)42(65-43(56)29-17-13-10-14-18-29)40-48(8,33(54)20-34-49(40,25-61-34)66-27(2)53)41-39(36(26)47(50,6)7)63-35(64-41)23-52-22-31-19-30(52)24-60-31/h9-18,30-35,37-42,54-55,59H,19-25H2,1-8H3,(H,51,58)/t30?,31?,32?,33?,34?,35?,37?,38?,39?,40-,41?,42-,48+,49-,50+/m0/s1
SMILES Code
CC1=C2C3C(OC(CN4CC5CC4CO5)O3)[C@@]6(C)[C@@H]([C@]7(OC(C)=O)COC7CC6O)[C@H](OC(C8=CC=CC=C8)=O)[C@@](CC1OC(C(O)C(NC(OC(C)(C)C)=O)C9=CC=CC=C9)=O)(O)C2(C)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
933.06
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Ding Y, Liu W, Lu C, Yang J, Zhu Y, Song Y, Ma Z, Yang L, Jia Y, Wen A. Preclinical pharmacokinetic analysis of felotaxel (SHR110008), a novel derivative of docetaxel, in rats and its protein binding ability in vitro. Biomed Pharmacother. 2012 Mar;66(2):98-102. doi: 10.1016/j.biopha.2011.11.012. PubMed PMID: 22264880.
2: Ding Y, Jia Y, Lu C, Liu W, Yang J, Song Y, Zhu Y, Yang L, Ding L, Wen A. In vitro assessment of cytochrome P450 inhibition and induction potential of felotaxel (SHR110008). Biomed Pharmacother. 2012 Jun;66(4):318-21. doi: 10.1016/j.biopha.2012.01.001. PubMed PMID: 22397757.
3: Ding Y, Lu C, Yang J, Jin X, Yang L, Wang C, Ma Z, Zhu Y, Ding L, Jia Y, Wen A. Application of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to the pharmacokinetics, tissue distribution and excretion studies of felotaxel (SHR110008) in tumor-bearing mice. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Mar 1;887-888:61-6. doi: 10.1016/j.jchromb.2012.01.010. PubMed PMID: 22309773.
4: Yan L, YanYan J, MinChun C, Jing Y, Ying S, ChengTao L, Jie G, CaiYang L, ZhenXing Z, AiDong W, Yi D. High-performance liquid chromatographic analysis of felotaxel, a novel anti-cancer drug, in rat plasma and in human plasma and urine. J Chromatogr Sci. 2013 Mar;51(3):292-6. doi: 10.1093/chromsci/bms140. PubMed PMID: 22933511.
