MedKoo Cat#: 529541 | Name: Strontium Malonate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Strontium Malonate is a calcium-sensing receptor agonist potentially for the treatment of postmenopausal osteoporosis.

Chemical Structure

Strontium Malonate
Strontium Malonate
CAS#63524-05-0 (malonate)

Theoretical Analysis

MedKoo Cat#: 529541

Name: Strontium Malonate

CAS#: 63524-05-0 (malonate)

Chemical Formula: C3H2O4Sr

Exact Mass:

Molecular Weight: 189.66

Elemental Analysis: C, 19.00; H, 1.06; O, 33.74; Sr, 46.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
141-82-2 (free acid) 63524-05-0 (malonate)
Synonym
NBS-101; NBS101; NBS 101
IUPAC/Chemical Name
Strontium Malonate
InChi Key
LVZZABGEQTZXHP-UHFFFAOYSA-L
InChi Code
InChI=1S/C3H4O4.Sr/c4-2(5)1-3(6)7;/h1H2,(H,4,5)(H,6,7);/q;+2/p-2
SMILES Code
O=C([O-])CC([O-])=O.[Sr+2]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 189.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Raffalt AC, Andersen JE, Christgau S. Application of inductively coupled plasma-mass spectrometry (ICP-MS) and quality assurance to study the incorporation of strontium into bone, bone marrow, and teeth of dogs after one month of treatment with strontium malonate. Anal Bioanal Chem. 2008 Jul;391(6):2199-207. doi: 10.1007/s00216-008-2171-0. PubMed PMID: 18496676. 2: Frankær CG, Raffalt AC, Stahl K. Strontium localization in bone tissue studied by X-ray absorption spectroscopy. Calcif Tissue Int. 2014 Feb;94(2):248-57. doi: 10.1007/s00223-013-9806-7. PubMed PMID: 24101232. 3: Bonhomme C, Gervais C, Folliet N, Pourpoint F, Diogo CC, Lao J, Jallot E, Lacroix J, Nedelec JM, Iuga D, Hanna JV, Smith ME, Xiang Y, Du J, Laurencin D. 87Sr solid-state NMR as a structurally sensitive tool for the investigation of materials: antiosteoporotic pharmaceuticals and bioactive glasses. J Am Chem Soc. 2012 Aug 1;134(30):12611-28. doi: 10.1021/ja303505g. PubMed PMID: 22738329. 4: Stahl K, Andersen JE, Christgau S. Strontium diibuprofenate dihydrate, strontium malonate sesquihydrate, strontium diascorbate dihydrate and strontium 2-oxidobenzoate hydrate at 120 K. Acta Crystallogr C. 2006 Apr;62(Pt 4):m144-9. PubMed PMID: 16598123. 5: Guo ML, Liu L, Lu CC. Poly[[μ(2)-aqua-tetraaquadi-μ(3)-malonato-nickel(II)strontium(II)] dihydrate]. Acta Crystallogr Sect E Struct Rep Online. 2010 Dec 4;67(Pt 1):m19-20. doi: 10.1107/S1600536810049779. PubMed PMID: 21522545; PubMed Central PMCID: PMC3050271. 6: Papachristodoulou CA, Assimakopoulos PA, Gangas NH. Strontium adsorption properties of an aluminum-pillared montmorillonite carrying carboxylate functional groups. J Colloid Interface Sci. 2002 Jan 1;245(1):32-9. PubMed PMID: 16290332. 7: Yost TL Jr, Fagan BC, Allain LR, Barnes CE, Dai S, Sepaniak MJ, Xue Z. Crown ether-doped sol-gel materials for strontium(II) separation. Anal Chem. 2000 Nov 1;72(21):5516-9. PubMed PMID: 11080909. 8: Prest JE, Baldock SJ, Fielden PR, Goddard NJ, Treves Brown BJ. A miniaturised isotachophoresis method for magnesium determination. Anal Bioanal Chem. 2009 Jul;394(5):1299-305. doi: 10.1007/s00216-009-2603-5. PubMed PMID: 19205676. 9: Luvisetto S, Cola C, Schmehl I, Azzone GF. Tracking of proton flow during transition from anaerobiosis to steady state. 2. Effect of cation uptake on the response of a hydrophobic membrane bound pH indicator. Eur J Biochem. 1991 Nov 15;202(1):121-30. PubMed PMID: 1718751. 10: Tomillero A, Moral MA. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2008 Sep;30(7):543-88. PubMed PMID: 18985183.