Sodium taurocholate | CAS#145-42-6 | CAS#81-24-3 | GPBAR1 protein agonist| MedKoo

MedKoo Cat#: 529535 | Name: Sodium taurocholate

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sodium taurocholate is a GPBAR1 protein agonist potentially for the treatment of type 2 diabetes and obesity in rats.

Chemical Structure

Sodium taurocholate

CAS#145-42-6 (sodium)

Theoretical Analysis

MedKoo Cat#: 529535

Name: Sodium taurocholate

CAS#: 145-42-6 (sodium)

Chemical Formula: C26H44NNaO7S

Exact Mass: 0.0000

Molecular Weight: 537.69

Elemental Analysis: C, 58.08; H, 8.25; N, 2.61; Na, 4.28; O, 20.83; S, 5.96

Price and Availability

Size	Price	Availability
5g	USD 350.00	2 Weeks
10g	USD 600.00	2 Weeks
25g	USD 1,150.00	2 Weeks

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Related CAS #

81-24-3 (free acid) 145-42-6 (sodium)

Synonym

Sodium taurocholate; Taurocholate sodium; Taurocholate sodium salt; Monosodium N-choloyltaurinate; Taurocholic acid sodium salt; Monosodium taurocholate; Ethanesulfonic Acid; TCA

IUPAC/Chemical Name

sodium 2-((R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)ethane-1-sulfonate

InChi Key

JAJWGJBVLPIOOH-IZYKLYLVSA-M

InChi Code

InChI=1S/C26H45NO7S.Na/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29;/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34);/q;+1/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-;/m1./s1

SMILES Code

C[C@H](CCC(NCCS(=O)([O-])=O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C.[Na+]

Appearance

Solid powder

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 537.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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J Virol. 2014 Mar;88(6):3273-84. doi: 10.1128/JVI.03478-13. PubMed PMID: 24390325; PubMed Central PMCID: PMC3957944. 5: Lv J, Gu WL, Chen CX. Effect of gentiopicroside on experimental acute pancreatitis induced by retrograde injection of sodium taurocholate into the biliopancreatic duct in rats. Fitoterapia. 2015 Apr;102:127-33. doi: 10.1016/j.fitote.2015.03.002. PubMed PMID: 25759121. 6: Jia G, Xiaoxiang W, Ruijie L, Xiaoxin Z, Xiaonan Y, Qing X, Ping X. Effect of Chaiqinchengqi decoction on inositol requiring enzyme 1α in alveolar macrophages of dogs with acute necrotising pancreatitis induced by sodium taurocholate. J Tradit Chin Med. 2015 Aug;35(4):434-9. PubMed PMID: 26427114. 7: Yan H, Li W. Sodium taurocholate cotransporting polypeptide acts as a receptor for hepatitis B and D virus. Dig Dis. 2015;33(3):388-96. doi: 10.1159/000371692. PubMed PMID: 26045274. 8: Shi Q, Liao KS, Zhao KL, Wang WX, Zuo T, Deng WH, Chen C, Yu J, Guo WY, He XB, Abliz A, Wang P, Zhao L. Hydrogen-rich saline attenuates acute renal injury in sodium taurocholate-induced severe acute pancreatitis by inhibiting ROS and NF-κB pathway. Mediators Inflamm. 2015;2015:685043. doi: 10.1155/2015/685043. PubMed PMID: 25878401; PubMed Central PMCID: PMC4386702. 9: Ni Y, Lempp FA, Mehrle S, Nkongolo S, Kaufman C, Fälth M, Stindt J, Königer C, Nassal M, Kubitz R, Sültmann H, Urban S. Hepatitis B and D viruses exploit sodium taurocholate co-transporting polypeptide for species-specific entry into hepatocytes. Gastroenterology. 2014 Apr;146(4):1070-83. doi: 10.1053/j.gastro.2013.12.024. PubMed PMID: 24361467. 10: Gu P, Liu RJ, Cheng ML, Wu Y, Zheng L, Liu YJ, Ma PC, Ding L. Simultaneous quantification of chlorogenic acid and taurocholic acid in human plasma by LC-MS/MS and its application to a pharmacokinetic study after oral administration of Shuanghua Baihe tablets. Chin J Nat Med. 2016 Apr;14(4):313-20. doi: 10.1016/S1875-5364(16)30034-6. PubMed PMID: 27114321. 11: Morrison JD. Prolonged stimulation of pancreatic serous secretions by bile and sodium taurocholate in anaesthetized rats. J Physiol Biochem. 2012 Dec;68(4):503-20. doi: 10.1007/s13105-012-0165-z. PubMed PMID: 22538870. 12: Yan H, Zhong G, Xu G, He W, Jing Z, Gao Z, Huang Y, Qi Y, Peng B, Wang H, Fu L, Song M, Chen P, Gao W, Ren B, Sun Y, Cai T, Feng X, Sui J, Li W. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. Elife. 2012 Nov 13;1:e00049. doi: 10.7554/eLife.00049. Erratum in: Elife. 2014;3:e05570. PubMed PMID: 23150796; PubMed Central PMCID: PMC3485615. 13: Prozorow-Krol B, Korolczuk A, Czechowska G, Slomka M, Madro A, Celinski K. The effects of the adenosine A3 receptor agonist IB-MECA on sodium taurocholate-induced experimental acute pancreatitis. Arch Pharm Res. 2013 Sep;36(9):1126-32. doi: 10.1007/s12272-013-0126-2. Erratum in: Arch Pharm Res. 2013 Sep;36(9):1167. PubMed PMID: 23625750; PubMed Central PMCID: PMC3766514. 14: Xue QM, Li N, Xue P, Wang CW, Wen Q. Therapeutic effects of electroacupuncture at ST36 acupoint on sodium-taurocholate-induced severe acute pancreatitis. Chin J Integr Med. 2014 Sep;20(9):695-700. doi: 10.1007/s11655-013-1331-4. PubMed PMID: 23893236. 15: Mo J, Yang A, Chen Z, Shao T, Zhang Y, Chen Q. Neuronostatin ameliorates sodium taurocholate-induced acute pancreatitis in rats. Dig Dis Sci. 2013 Oct;58(10):2903-7. PubMed PMID: 23959212. 16: Khatun Z, Nurunnabi, Cho KJ, Byun Y, Bae YH, Lee YK. Oral absorption mechanism and anti-angiogenesis effect of taurocholic acid-linked heparin-docetaxel conjugates. J Control Release. 2014 Mar 10;177:64-73. doi: 10.1016/j.jconrel.2013.12.034. PubMed PMID: 24412572. 17: Dolinsky BM, Zelig CM, Paonessa DJ, Hoeldtke NJ, Napolitano PG. Effect of taurocholic acid on fetoplacental arterial pressures in a dual perfusion placental cotyledon model: a novel approach to intrahepatic cholestasis of pregnancy. J Reprod Med. 2014 Jul-Aug;59(7-8):367-70. PubMed PMID: 25098026. 18: Yan H, Peng B, He W, Zhong G, Qi Y, Ren B, Gao Z, Jing Z, Song M, Xu G, Sui J, Li W. Molecular determinants of hepatitis B and D virus entry restriction in mouse sodium taurocholate cotransporting polypeptide. J Virol. 2013 Jul;87(14):7977-91. doi: 10.1128/JVI.03540-12. PubMed PMID: 23678176; PubMed Central PMCID: PMC3700185. 19: Khatun Z, Nurunnabi M, Reeck GR, Cho KJ, Lee YK. Oral delivery of taurocholic acid linked heparin-docetaxel conjugates for cancer therapy. J Control Release. 2013 Aug 28;170(1):74-82. doi: 10.1016/j.jconrel.2013.04.024. PubMed PMID: 23665255. 20: Xiao WQ, Yin GJ, Fan YT, Qiu L, Cang XF, Yu G, Hu YL, Xing M, Wu DQ, Wang XP, Hu GY, Wan R. Catalpol ameliorates sodium taurocholate-induced acute pancreatitis in rats via inhibiting activation of nuclear factor kappa B. Int J Mol Sci. 2014 Jul 4;15(7):11957-72. doi: 10.3390/ijms150711957. PubMed PMID: 25000266; PubMed Central PMCID: PMC4139823.