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MedKoo Cat#: 513683 | Name: CGP 56999A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CGP 56999A is a GABA(B) receptor antagonist, which enhances expression of brain-derived neurotrophic factor and attenuates dopamine depletion in the rat corpus striatum.

Chemical Structure

CGP 56999A
CGP 56999A
CAS#153994-97-9

Theoretical Analysis

MedKoo Cat#: 513683

Name: CGP 56999A

CAS#: 153994-97-9

Chemical Formula: C19H30NO5P

Exact Mass: 383.1862

Molecular Weight: 383.42

Elemental Analysis: C, 59.52; H, 7.89; N, 3.65; O, 20.86; P, 8.08

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CGP 56999A; CGP56999A; CGP-56999A .
IUPAC/Chemical Name
3-[(1R)-1-[[(2S)-3-(cyclohexylmethyl-hydroxyphosphoryl)-2-hydroxypropyl]amino]ethyl]benzoic acid
InChi Key
NLWRVVKVUYDPTH-ZIYGTXEKSA-N
InChi Code
InChI=1S/C19H30NO5P/c1-14(15-7-6-8-16(11-15)19(22)23)20-12-17(21)13-26(2,24)25-18-9-4-3-5-10-18/h6-8,11,14,17-18,20-21H,3-5,9-10,12-13H2,1-2H3,(H,22,23)/t14-,17+,26?/m1/s1
SMILES Code
O=C(O)C1=CC=CC([C@H](NC[C@H](O)CP(OC2CCCCC2)(C)=O)C)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 383.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Enna SJ, Reisman SA, Stanford JA. CGP 56999A, a GABA(B) receptor antagonist, enhances expression of brain-derived neurotrophic factor and attenuates dopamine depletion in the rat corpus striatum following a 6-hydroxydopamine lesion of the nigrostriatal pathway. Neurosci Lett. 2006 Oct 2;406(1-2):102-6. PubMed PMID: 16890350. 2: Tsai ML, Crutchley M, Boyce R, Ma J, Boon F, Cain DP, Leung LS. Long-lasting auditory gating deficit accompanied by GABA(B) receptor dysfunction in the hippocampus after early-life limbic seizures in rats. Physiol Behav. 2012 Jun 25;106(4):534-41. doi: 10.1016/j.physbeh.2012.03.033. PubMed PMID: 22504497.