Related CAS #
712260-52-1 (Piperphentonamine free base)
IUPAC/Chemical Name
(E)-5-((2-(benzo[d][1,3]dioxol-5-yl)ethyl)(methyl)amino)-1-(4-hydroxyphenyl)pent-1-en-3-one hydrochloride
InChi Key
MXVIFUCWSSCOCK-ZFXMFRGYSA-N
InChi Code
InChI=1S/C21H23NO4.ClH/c1-22(12-10-17-5-9-20-21(14-17)26-15-25-20)13-11-19(24)8-4-16-2-6-18(23)7-3-16;/h2-9,14,23H,10-13,15H2,1H3;1H/b8-4+;
SMILES Code
O=C(CCN(CCC1=CC=C(OCO2)C2=C1)C)/C=C/C3=CC=C(O)C=C3.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
389.87
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Shi A, Hu X, Li K, Li J, Han L, Wan H, Li R. Determination of piperphentonamine and metabolites M1 and M6 in human plasma and urine by LC/MS/MS and its application in a pharmacokinetics study in Chinese healthy volunteers. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Nov 1;908:87-93. doi: 10.1016/j.jchromb.2012.09.031. PubMed PMID: 23122405.
2: Bin J, Wang Q, Zhuo YY, Xu JP, Zhang HT. Piperphentonamine (PPTA) attenuated cerebral ischemia-induced memory deficits via neuroprotection associated with anti-apoptotic activity. Metab Brain Dis. 2012 Dec;27(4):495-505. doi: 10.1007/s11011-012-9330-x. PubMed PMID: 22843383.
3: Li Y, Li W, Wu J, Chen H, Wan L. [Effect of piperphentonamine hydrochloride on expressions of interleukin-1β and TNF-α mRNA and Fas protein in guinea pigs with cochlear ischemia/reperfusion injury]. Nan Fang Yi Ke Da Xue Xue Bao. 2013 Nov;33(11):1669-72. Chinese. PubMed PMID: 24273275.
4: Zhu HY, Bin J, Wang C, Lin HB, Zhou H, Xu JP. [Effects of piperphentonamine hydrochloride on cognitive deficits in rats induced by cerebral ischemia-reperfusion]. Nan Fang Yi Ke Da Xue Xue Bao. 2011 Nov;31(11):1858-62. Chinese. PubMed PMID: 22126765.
5: Li BB, Wu J, Chen J, Chen H, Li YH. [Protective effect of peperphentonamine injection through the otocyst against gentamicin- induced cochlear damage in guinea pigs]. Nan Fang Yi Ke Da Xue Xue Bao. 2016 Apr;36(4):557-61. Chinese. PubMed PMID: 27113187.
6: Chen H, Xie M, Wu J, Li W, Li Y. [Peperphentonamine hydrochloride protects against gentamicin-induced cochlea damage by lowering cochlear caspase-3 expression in guinea pigs]. Nan Fang Yi Ke Da Xue Xue Bao. 2014 Mar;34(3):329-34. Chinese. PubMed PMID: 24670443.
