MedKoo Cat#: 529523 | Name: L-Clausenamide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L-clausenamide is potentially for the treatment of Alzheimer's disease via multi-target effects.

Chemical Structure

L-Clausenamide
L-Clausenamide
CAS#201529-58-0 (3S4R5R isomer)

Theoretical Analysis

MedKoo Cat#: 529523

Name: L-Clausenamide

CAS#: 201529-58-0 (3S4R5R isomer)

Chemical Formula: C18H19NO3

Exact Mass: 297.1365

Molecular Weight: 297.35

Elemental Analysis: C, 72.71; H, 6.44; N, 4.71; O, 16.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
L-Clausenamide; (-)-Clausenamide
IUPAC/Chemical Name
(3S,4R,5R)-3-hydroxy-5-((S)-hydroxy(phenyl)methyl)-1-methyl-4-phenylpyrrolidin-2-one
InChi Key
WGYGSZOQGYRGIP-NCOADZHNSA-N
InChi Code
InChI=1S/C18H19NO3/c1-19-15(16(20)13-10-6-3-7-11-13)14(17(21)18(19)22)12-8-4-2-5-9-12/h2-11,14-17,20-21H,1H3/t14-,15-,16+,17+/m1/s1
SMILES Code
O=C1N(C)[C@@H]([C@@H](O)C2=CC=CC=C2)[C@@H](C3=CC=CC=C3)[C@@H]1O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 297.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liu SL, Zhang JT. Effects of naloxone on l-clausenamide-induced long-term potentiation in dentate gyrus of anesthetized rats. Zhongguo Yao Li Xue Bao. 1999 Feb;20(2):112-6. PubMed PMID: 10437155. 2: Zhao MR, Zhang JT. Effects of 7-nitroindazole on long-term potentiation induced by l-clausenamide and high-frequency stimulation in rat hippocampus in vivo. Zhongguo Yao Li Xue Bao. 1999 Apr;20(4):319-23. PubMed PMID: 10452116.