Synonym
(±)-BAY-K-8644; BAYK 8644; BAYK8644; BAYK-8644; BAY K 8644; BAY K8644; BA YK-8644;
IUPAC/Chemical Name
methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate
InChi Key
ZFLWDHHVRRZMEI-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3
SMILES Code
O=C(C1=C(C)NC(C)=C([N+]([O-])=O)C1C2=CC=CC=C2C(F)(F)F)OC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
356.30
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lai ZR, Chou CT, Liu SI, Liang WZ, Huang JK, Jan CR. Effect of BayK 8644 on [Ca²⁺]i and viability in PC3 human prostate cancer cells. Chin J Physiol. 2013 Dec 31;56(6):318-25. doi: 10.4077/CJP.2013.BAB161. Erratum in: Chin J Physiol. 2014 Feb 28;57(1):60. PubMed PMID: 24495178.
2: Marom M, Hagalili Y, Sebag A, Tzvier L, Atlas D. Conformational changes induced in voltage-gated calcium channel Cav1.2 by BayK 8644 or FPL64176 modify the kinetics of secretion independently of Ca2+ influx. J Biol Chem. 2010 Mar 5;285(10):6996-7005. doi: 10.1074/jbc.M109.059865. PubMed PMID: 20054004; PubMed Central PMCID: PMC2844149.
3: Turner CP, Debenedetto D, Liu C. NMDAR blockade-induced neonatal brain injury: Reversal by the calcium channel agonist BayK 8644. Neurosci Lett. 2009 Feb 6;450(3):292-5. doi: 10.1016/j.neulet.2008.12.002. PubMed PMID: 19070650; PubMed Central PMCID: PMC2699449.
4: Kuzmenkin A, Hang C, Kuzmenkina E, Jurkat-Rott K. Gating of the HypoPP-1 mutations: II. Effects of a calcium-channel agonist BayK 8644. Pflugers Arch. 2007 Jul;454(4):605-14. PubMed PMID: 17333247.
5: Artigas P, Ferreira G, Reyes N, Brum G, Pizarro G. Effects of the enantiomers of BayK 8644 on the charge movement of L-type Ca channels in guinea-pig ventricular myocytes. J Membr Biol. 2003 Jun 1;193(3):215-27. PubMed PMID: 12962282.
6: Katoh H, Schlotthauer K, Bers DM. Transmission of information from cardiac dihydropyridine receptor to ryanodine receptor: evidence from BayK 8644 effects on resting Ca(2+) sparks. Circ Res. 2000 Jul 21;87(2):106-11. PubMed PMID: 10903993.
7: Satoh H, Hayashi H, Blatter LA, Bers DM. BayK 8644 increases resting calcium spark frequency in ferret ventricular myocytes. Heart Vessels. 1997;Suppl 12:58-61. PubMed PMID: 9476545.
8: Tusell JM, Barron S, Serratosa J. Anticonvulsant activity of calmodulin antagonist W-7 in convulsions induced by lindane and BayK-8644: effects in c-fos expression. Neurotoxicology. 1994 Fall;15(3):751-6. PubMed PMID: 7531829.
9: Bartrup JT, Stone TW. Inhibition of adenosine responses of rat hippocampal neurones by nifedipine and BAYK 8644. Brain Res. 1990 Aug 20;525(2):315-8. PubMed PMID: 1701332.
10: Yu C, Jia M, Litzinger M, Nelson PG. Calcium agonist (BayK 8644) augments voltage-sensitive calcium currents but not synaptic transmission in cultured mouse spinal cord neurons. Exp Brain Res. 1988;71(3):467-74. PubMed PMID: 2458275.
11: Fredholm BB, Hu PS, Lindgren E. The dihydropyridine calcium-channel agonist BayK 8644 inhibits the presynaptic effects of R-phenylisopropyl adenosine in the rat hippocampus. Acta Physiol Scand. 1986 Dec;128(4):659-60. PubMed PMID: 2433900.
