MedKoo Cat#: 531543 | Name: AZD6703 free base
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

AZD6703 is a potent, selective and reversible orally bioavailable inhibitor of p38 mitogen-activated protein kinase 14 (MAPK14).

Chemical Structure

AZD6703 free base
AZD6703 free base
CAS# 851845-37-9 (free base)

Theoretical Analysis

MedKoo Cat#: 531543

Name: AZD6703 free base

CAS#: 851845-37-9 (free base)

Chemical Formula: C24H27N5O2

Exact Mass: 417.2165

Molecular Weight: 417.51

Elemental Analysis: C, 69.04; H, 6.52; N, 16.77; O, 7.66

Price and Availability

Size Price Availability Quantity
5mg USD 250.00 Ready to Ship
10mg USD 450.00 Ready to Ship
25mg USD 750.00 Ready to Ship
50mg USD 1,250.00 Ready to Ship
100mg USD 2,150.00 Ready to Ship
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Related CAS #
851845-37-9 (free base) 851846-65-6 (HCl) 851846-76-9 (mesylate).
Synonym
AZD6703; AZD 6703; AZD-6703.
IUPAC/Chemical Name
N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3-yl]benzamide
InChi Key
ZMAZXHICVRYLQN-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H27N5O2/c1-16-3-4-17(23(30)26-18-5-6-18)13-22(16)29-15-25-21-8-7-19(14-20(21)24(29)31)28-11-9-27(2)10-12-28/h3-4,7-8,13-15,18H,5-6,9-12H2,1-2H3,(H,26,30)
SMILES Code
O=C(NC1CC1)C2=CC=C(C)C(N3C=NC4=C(C=C(N5CCN(C)CC5)C=C4)C3=O)=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Certificate of Analysis
Safety Data Sheet (SDS)
Biological target:
AZD6703 is a potent, selective and reversible orally bioavailable inhibitor of p38 mitogen-activated protein kinase 14 (MAPK14).
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 417.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Brown DS, Cumming JG, Bethel P, Finlayson J, Gerhardt S, Nash I, Pauptit RA, Pike KG, Reid A, Snelson W, Swallow S, Thompson C. The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]ben zamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3879-83. doi: 10.1016/j.bmcl.2012.04.116. PubMed PMID: 22608965.