Synonym
Hexasodium phytate; Hexasodium-phytate; SNF-472; SNF472; SNF 472; Fytate d'hexasodium; Fitato de hexasodio;
IUPAC/Chemical Name
sodium cyclohexane-1,2,3,4,5,6-hexayl hexakis(hydrogen phosphate)
InChi Key
DHZIAGCFFSRULK-UHFFFAOYSA-H
InChi Code
InChI=1S/C6H18O24P6.6Na/c7-31(8,9)25-1-2(26-32(10,11)12)4(28-34(16,17)18)6(30-36(22,23)24)5(29-35(19,20)21)3(1)27-33(13,14)15;;;;;;/h1-6H,(H2,7,8,9)(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)(H2,19,20,21)(H2,22,23,24);;;;;;/q;6*+1/p-6
SMILES Code
O=P(OC1C(OP([O-])(O)=O)C(OP([O-])(O)=O)C(OP([O-])(O)=O)C(OP([O-])(O)=O)C1OP([O-])(O)=O)([O-])O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
791.92
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Zabirnyk A, Ferrer MD, Bogdanova M, Pérez MM, Salcedo C, Kaljusto ML, Kvitting JP, Stensløkken KO, Perelló J, Vaage J. SNF472, a novel anti- crystallization agent, inhibits induced calcification in an in vitro model of human aortic valve calcification. Vascul Pharmacol. 2019 Nov-Dec;122-123:106583. doi: 10.1016/j.vph.2019.106583. Epub 2019 Aug 19. PMID: 31437530.
2: Creeth JE, Parkinson CR, Burnett GR, Sanyal S, Lippert F, Zero DT, Hara AT. Effects of a sodium fluoride- and phytate-containing dentifrice on remineralisation of enamel erosive lesions-an in situ randomised clinical study. Clin Oral Investig. 2018 Sep;22(7):2543-2552. doi: 10.1007/s00784-018-2351-z. Epub 2018 Feb 8. PMID: 29423713; PMCID: PMC6097037.
3: Milleman KR, Creeth JE, Burnett GR, Milleman JL. A randomized clinical trial to evaluate the stain removal efficacy of a sodium phytate dentifrice formulation. J Esthet Restor Dent. 2018 Mar;30(2):E45-E51. doi: 10.1111/jerd.12355. Epub 2018 Feb 7. PMID: 29411532; PMCID: PMC5969293.
4: Perelló J, Gómez M, Ferrer MD, Rodríguez NY, Salcedo C, Buades JM, Pérez MM, Torregrosa JV, Martín E, Maduell F. SNF472, a novel inhibitor of vascular calcification, could be administered during hemodialysis to attain potentially therapeutic phytate levels. J Nephrol. 2018 Apr;31(2):287-296. doi: 10.1007/s40620-018-0471-9. Epub 2018 Jan 19. PMID: 29350348; PMCID: PMC5829128.
