RTI-371 | CAS#652978-45-5

MedKoo Cat#: 530476 | Name: RTI-371

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RTI-371, also known as RTI-4229-371, is a potent and selective dopamine reuptake inhibitor in vitro. RTI-371 and several other DAT-selective inhibitors with atypical actions on locomotor behaviour increased the efficacy of CP55940 in a concentration-dependent manner.

Chemical Structure

RTI-371

CAS#652978-45-5

Theoretical Analysis

MedKoo Cat#: 530476

Name: RTI-371

CAS#: 652978-45-5

Chemical Formula: C24H25ClN2O

Exact Mass: 392.1655

Molecular Weight: 392.93

Elemental Analysis: Chemical Formula: C24H25ClN2O Exact Mass: 392.1655 Molecular Weight: 392.9270 Elemental Analysis: C, 73.36; H, 6.41; Cl, 9.02; N, 7.13; O, 4.07

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

RTI-4229-371; RTI 4229-371; RTI4229-371; RTI-371; RTI371; RTI 371.

IUPAC/Chemical Name

3-(4-chlorophenyl)-5-((1S,2S,3S,5R)-8-methyl-3-(p-tolyl)-8-azabicyclo[3.2.1]octan-2-yl)isoxazole

InChi Key

MUVQRHMVRFZUGP-WOOVXOMTSA-N

InChi Code

InChI=1S/C24H25ClN2O/c1-15-3-5-16(6-4-15)20-13-19-11-12-22(27(19)2)24(20)23-14-21(26-28-23)17-7-9-18(25)10-8-17/h3-10,14,19-20,22,24H,11-13H2,1-2H3/t19-,20-,22+,24+/m1/s1

SMILES Code

[H][C@@]12[C@@H](C3=CC(C4=CC=C(Cl)C=C4)=NO3)[C@@H](C5=CC=C(C)C=C5)C[C@@](CC1)(N2C)[H]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 392.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Navarro HA, Howard JL, Pollard GT, Carroll FI. Positive allosteric modulation of the human cannabinoid (CB) receptor by RTI-371, a selective inhibitor of the dopamine transporter. Br J Pharmacol. 2009 Apr;156(7):1178-84. doi: 10.1111/j.1476-5381.2009.00124.x. PubMed PMID: 19226282; PubMed Central PMCID: PMC2697692. 2: Hiranita T, Wilkinson DS, Hong WC, Zou MF, Kopajtic TA, Soto PL, Lupica CR, Newman AH, Katz JL. 2-isoxazol-3-phenyltropane derivatives of cocaine: molecular and atypical system effects at the dopamine transporter. J Pharmacol Exp Ther. 2014 May;349(2):297-309. doi: 10.1124/jpet.113.212738. Erratum in: J Pharmacol Exp Ther. 2014 Jun 1;349(3):534. PubMed PMID: 24518035; PubMed Central PMCID: PMC3989806. 3: Carroll FI, Pawlush N, Kuhar MJ, Pollard GT, Howard JL. Synthesis, monoamine transporter binding properties, and behavioral pharmacology of a series of 3beta-(substituted phenyl)-2beta-(3'-substituted isoxazol-5-yl)tropanes. J Med Chem. 2004 Jan 15;47(2):296-302. PubMed PMID: 14711303.