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MedKoo Cat#: 407361 | Name: AK301

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AK301 is a potent and selective inhibitor of tubulin polymerization and an effective sensitizer of cancer cells to apoptotic ligands (EC50 < 200 nM). Colon cancer cells arrested in mitosis with AK301 readily underwent a p53-dependent apoptosis following compound withdrawal and arrest release. This apoptotic response was significantly higher for AK301 than for other mitotic inhibitors tested (colchicine, vincristine, and BI 2536).

Chemical Structure

AK301
AK301
CAS#314022-97-4

Theoretical Analysis

MedKoo Cat#: 407361

Name: AK301

CAS#: 314022-97-4

Chemical Formula: C19H21ClN2O2

Exact Mass: 344.1292

Molecular Weight: 344.84

Elemental Analysis: C, 66.18; H, 6.14; Cl, 10.28; N, 8.12; O, 9.28

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AK301; AK-301; AK 301.
IUPAC/Chemical Name
(4-(3-chlorophenyl)piperazin-1-yl)(2-ethoxyphenyl)methanone
InChi Key
UTBDVNWZTNDVJV-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H21ClN2O2/c1-2-24-18-9-4-3-8-17(18)19(23)22-12-10-21(11-13-22)16-7-5-6-15(20)14-16/h3-9,14H,2,10-13H2,1H3
SMILES Code
ClC1=CC(N2CCN(C(C3=C(OCC)C=CC=C3)=O)CC2)=CC=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 344.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chopra A, Bond MJ, Bleiler M, Yeagley M, Wright D, Giardina C. Efficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301. PLoS One. 2016 Apr 20;11(4):e0153818. doi: 10.1371/journal.pone.0153818. PubMed PMID: 27097159; PubMed Central PMCID: PMC4838221. 2: Chopra A, Anderson A, Giardina C. Novel piperazine-based compounds inhibit microtubule dynamics and sensitize colon cancer cells to tumor necrosis factor-induced apoptosis. J Biol Chem. 2014 Jan 31;289(5):2978-91. doi: 10.1074/jbc.M113.499319. PubMed PMID: 24338023; PubMed Central PMCID: PMC3908429.