Synonym
Guanoclor; Guanochlor; Guanochlorine; Vatensol; Guanocloro; Guanoclorum; NSC-108163; NSC108163; NSC 108163
IUPAC/Chemical Name
2-(2-(2,6-dichlorophenoxy)ethyl)hydrazine-1-carboximidamide
InChi Key
XIHXRRMCNSMUET-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H12Cl2N4O/c10-6-2-1-3-7(11)8(6)16-5-4-14-15-9(12)13/h1-3,14H,4-5H2,(H4,12,13,15)
SMILES Code
N=C(NNCCOC1=C(Cl)C=CC=C1Cl)N
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
263.12
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: SINNIAH R, GATENBY PB. CLINICOPHARMACOLOGICAL ASSESSMENT OF THE NEW ANTI-HYPERTENSIVE COMPOUND GUANOCLOR (VATENSOL). Ir J Med Sci. 1965 Mar;471:111-24. PubMed PMID: 14295356.
2: BENDER S. TO-DAY'S DRUGS. GUANOCLOR. Br Med J. 1964 Jul 25;2(5403):238-9. PubMed PMID: 14150915; PubMed Central PMCID: PMC1817852.
3: Mackinnon J, el-Baz LM. A comparison of guanoclor and methyldopa in the treatment of severe hypertension. Br J Clin Pract. 1971 Mar;25(3):135-7. PubMed PMID: 4929159.
4: Mehta AB, Biswas AK, Pinto IJ, Sheth UK. Clinical assessment of the new antihypertensive Compound--1029 (Vatensol)--Guanoclor. Indian Heart J. 1967 Oct;19(4):322-8. PubMed PMID: 4870898.
5: Lawrie TD. Current therapeutics CXXXV.--Guanoclor. Practitioner. 1967 Aug;199(190):239-43. PubMed PMID: 6058648.
6: Hodge JV. Guanoclor as an antihypertensive drug. Br Med J. 1966 Oct 22;2(5520):981-4. PubMed PMID: 5921741; PubMed Central PMCID: PMC1944426.
7: Wahbi AA, Bedair MM, Galal SM, Gazy AA. Spectrophotometric analysis of some guanidino drugs by acid-dye and charge-transfer complexation methods. J Pharm Biomed Anal. 1993 Aug;11(8):639-45. PubMed PMID: 8257728.
8: Frelin C, Vigne P, Barbry P, Lazdunski M. Interaction of guanidinium and guanidinium derivatives with the Na+/H+ exchange system. Eur J Biochem. 1986 Jan 15;154(2):241-5. PubMed PMID: 3002793.
9: Vigne P, Lazdunski M, Frelin C. Guanabenz, guanochlor, guanoxan and idazoxan bind with high affinity to non-adrenergic sites in pig kidney membranes. Eur J Pharmacol. 1989 Jan 31;160(2):295-8. PubMed PMID: 2527160.
10: LAWRIE TD, LORIMER AR, MCALPINE SG, REINERT H. CLINICAL TRIAL AND PHARMACOLOGICAL STUDY OF COMPOUND 1029. ("VATENSOL"). Br Med J. 1964 Feb 15;1(5380):402-6. PubMed PMID: 14085968; PubMed Central PMCID: PMC1813383.
11: Ham NS. Conformational populations for antihistamines and antihypertensives in solution. J Pharm Sci. 1976 Apr;65(4):612-4. PubMed PMID: 5591.
