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MedKoo Cat#: 531467 | Name: ARI-3099 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ARI-3099 is an inhibitor of fibroblast activation protein, alpha (FAP).

Chemical Structure

ARI-3099 HCl
CAS#1432499-49-4 (free base)

Theoretical Analysis

MedKoo Cat#: 531467

Name: ARI-3099 HCl

CAS#: 1432499-49-4 (free base)

Chemical Formula: C13H17BClN3O4

Exact Mass:

Molecular Weight: 325.56

Elemental Analysis: C, 47.96; H, 5.26; B, 3.32; Cl, 10.89; N, 12.91; O, 19.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1432499-49-4 (free base) unknown (HCl)
Synonym
ARI-3099 ; ARI3099; ARI 3099
IUPAC/Chemical Name
B-[(2R)-1-[(2R)-1-Oxo-2-[(4-pyridinylcarbonyl)amino]propyl]-2-pyrrolidinyl]boronic acid hydrochloride
InChi Key
LCAILAILGOZQNE-SBSPUUFOSA-N
InChi Code
InChI=1S/C13H16BN3O4.ClH/c1-9(16-11(18)10-3-6-15-7-4-10)12(19)17-8-2-5-14(17)13(20)21;/h3-4,6-7,9H,2,5,8H2,1H3,(H,16,18)(H,20,21);1H/t9-;/m1./s1
SMILES Code
O=C(O)B1N(C([C@@H](C)NC(C2=CC=NC=C2)=O)=O)CCC1.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 325.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Coppage AL, Heard KR, DiMare MT, Liu Y, Wu W, Lai JH, Bachovchin WW. Human FGF-21 Is a Substrate of Fibroblast Activation Protein. PLoS One. 2016 Mar 10;11(3):e0151269. doi: 10.1371/journal.pone.0151269. PubMed PMID: 26962859; PubMed Central PMCID: PMC4786124. 2: Poplawski SE, Lai JH, Li Y, Jin Z, Liu Y, Wu W, Wu Y, Zhou Y, Sudmeier JL, Sanford DG, Bachovchin WW. Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase. J Med Chem. 2013 May 9;56(9):3467-77. doi: 10.1021/jm400351a. PubMed PMID: 23594271; PubMed Central PMCID: PMC4059180.