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MedKoo Cat#: 531457 | Name: AMN082 HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

AMN082 is an mGluR II and III activator.

Chemical Structure

AMN082 HCl
AMN082 HCl
CAS#97075-46-2 (HCl)

Theoretical Analysis

MedKoo Cat#: 531457

Name: AMN082 HCl

CAS#: 97075-46-2 (HCl)

Chemical Formula: C28H30Cl2N2

Exact Mass: 392.2252

Molecular Weight: 465.46

Elemental Analysis: C, 72.25; H, 6.50; Cl, 15.23; N, 6.02

Price and Availability

Size Price Availability Quantity
25mg USD 400.00 2 Weeks
50mg USD 750.00 2 Weeks
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Related CAS #
83027-13-8 (free base) 97075-46-2 (HCl)
Synonym
AMN 082; AMN-082; AMN082; AMN082 Dihydrochloride; AMN082 2HCl; AMN082 HCl.
IUPAC/Chemical Name
N,N'-bis[di(phenyl)methyl]ethane-1,2-diamine dihydrochloride
InChi Key
YRQCDCNQANSUPB-UHFFFAOYSA-N
InChi Code
InChI=1S/C28H28N2.2ClH/c1-5-13-23(14-6-1)27(24-15-7-2-8-16-24)29-21-22-30-28(25-17-9-3-10-18-25)26-19-11-4-12-20-26;;/h1-20,27-30H,21-22H2;2*1H
SMILES Code
[H]Cl.[H]Cl.C(NCCNC(C1=CC=CC=C1)C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 465.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Jantas D, Gręda A, Gołda S, Korostyński M, Lasoń W. The neuroprotective effects of orthosteric agonists of group II and III mGluRs in primary neuronal cell cultures are dependent on developmental stage. Neuropharmacology. 2016 Dec;111:195-211. doi: 10.1016/j.neuropharm.2016.09.003. PubMed PMID: 27600687. 2: Wei X, Yang D, Shi T, Wang J, Deng Y, Qiao X, Yang C, Xu MY. Metabotropic Glutamate Receptor 7 (mGluR7) as a Target for the Modulating Pain-Evoked Activities of Neurons in the Hippocampal CA3 Region of Rats. CNS Neurol Disord Drug Targets. 2016 Aug 1. [Epub ahead of print] PubMed PMID: 27488423. 3: Palazzo E, Marabese I, de Novellis V, Rossi F, Maione S. Metabotropic Glutamate Receptor 7: From Synaptic Function to Therapeutic Implications. Curr Neuropharmacol. 2016;14(5):504-13. Review. PubMed PMID: 27306064; PubMed Central PMCID: PMC4983754. 4: Kahl E, Fendt M. Metabotropic Glutamate Receptors 7 within the Nucleus Accumbens are Involved in Relief Learning in Rats. Curr Neuropharmacol. 2016;14(5):405-12. Review. PubMed PMID: 27296637; PubMed Central PMCID: PMC4983753. 5: Ahnaou A, Raeyemaekers L, Huysmans H, Drinkenburg WH. Off-target potential of AMN082 on sleep EEG and related physiological variables: Evidence from mGluR7 (-/-) mice. Behav Brain Res. 2016 Sep 15;311:287-97. doi: 10.1016/j.bbr.2016.05.035. PubMed PMID: 27211063. 6: Wang WY, Wu XM, Jia LJ, Zhang HH, Cai F, Mao H, Xu WC, Chen L, Zhang J, Hu SF. Beta-arrestin1 and 2 differently modulate metabotropic glutamate receptor 7 signaling in rat developmental sevoflurane-induced neuronal apoptosis. Neuroscience. 2016 Jan 28;313:199-212. doi: 10.1016/j.neuroscience.2015.11.038. PubMed PMID: 26621121. 7: Li X, Markou A. Metabotropic Glutamate Receptor 7 (mGluR7) as a Target for the Treatment of Psychostimulant Dependence. CNS Neurol Disord Drug Targets. 2015;14(6):738-44. Review. PubMed PMID: 26022263; PubMed Central PMCID: PMC4562387. 8: Gregory KJ, Conn PJ. Molecular Insights into Metabotropic Glutamate Receptor Allosteric Modulation. Mol Pharmacol. 2015 Jul;88(1):188-202. doi: 10.1124/mol.114.097220. PubMed PMID: 25808929; PubMed Central PMCID: PMC4468636. 9: Jantas D, Greda A, Leskiewicz M, Grygier B, Pilc A, Lason W. Neuroprotective effects of mGluR II and III activators against staurosporine- and doxorubicin-induced cellular injury in SH-SY5Y cells: New evidence for a mechanism involving inhibition of AIF translocation. Neurochem Int. 2015 Sep;88:124-37. doi: 10.1016/j.neuint.2014.12.011. PubMed PMID: 25661514. 10: Domin H, Jantas D, Śmiałowska M. Neuroprotective effects of the allosteric agonist of metabotropic glutamate receptor 7 AMN082 on oxygen-glucose deprivation- and kainate-induced neuronal cell death. Neurochem Int. 2015 Sep;88:110-23. doi: 10.1016/j.neuint.2014.12.010. PubMed PMID: 25576184. 11: Jenda M, Gawel K, Marszalek M, Komsta L, Kotlinska JH. AMN082, a metabotropic glutamate receptor 7 allosteric agonist, attenuates locomotor sensitization and cross-sensitization induced by cocaine and morphine in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Mar 3;57:166-75. doi: 10.1016/j.pnpbp.2014.11.004. PubMed PMID: 25448778. 12: G S, Suvarna P, Hadigal S, Kamath P, Prabhu N, Shenoy K A, Lc P. Can Metabotropic Glutamate Receptor 7 (mGluR 7) be a Novel Target for Analgesia? J Clin Diagn Res. 2014 Sep;8(9):HC16-8. doi: 10.7860/JCDR/2014/10377.4884. PubMed PMID: 25386457; PubMed Central PMCID: PMC4225909. 13: Jantas D, Greda A, Golda S, Korostynski M, Grygier B, Roman A, Pilc A, Lason W. Neuroprotective effects of metabotropic glutamate receptor group II and III activators against MPP(+)-induced cell death in human neuroblastoma SH-SY5Y cells: the impact of cell differentiation state. Neuropharmacology. 2014 Aug;83:36-53. doi: 10.1016/j.neuropharm.2014.03.019. PubMed PMID: 24713472. 14: Pałucha-Poniewiera A, Szewczyk B, Pilc A. Activation of the mTOR signaling pathway in the antidepressant-like activity of the mGlu5 antagonist MTEP and the mGlu7 agonist AMN082 in the FST in rats. Neuropharmacology. 2014 Jul;82:59-68. doi: 10.1016/j.neuropharm.2014.03.001. PubMed PMID: 24631968. 15: Sun N, Kong L, Niu L, Zhu J, Xu Y, Du J. [Ventrolateral periaqueductal gray metabotropic glutamate receptor subtypes 7 and 8 mediate opposite effects on cardiosomatic motor reflex in rats]. Nan Fang Yi Ke Da Xue Xue Bao. 2014 Jan;34(1):8-13. Chinese. PubMed PMID: 24463108. 16: Konieczny J, Lenda T. Contribution of the mGluR7 receptor to antiparkinsonian-like effects in rats: a behavioral study with the selective agonist AMN082. Pharmacol Rep. 2013;65(5):1194-203. PubMed PMID: 24399715. 17: Iacovelli L, Felicioni M, Nisticò R, Nicoletti F, De Blasi A. Selective regulation of recombinantly expressed mGlu7 metabotropic glutamate receptors by G protein-coupled receptor kinases and arrestins. Neuropharmacology. 2014 Feb;77:303-12. doi: 10.1016/j.neuropharm.2013.10.013. PubMed PMID: 24148810. 18: Yamasaki T, Kumata K, Yui J, Fujinaga M, Furutsuka K, Hatori A, Xie L, Ogawa M, Nengaki N, Kawamura K, Zhang MR. Synthesis and evaluation of [11C]MMPIP as a potential radioligand for imaging of metabotropic glutamate 7 receptor in the brain. EJNMMI Res. 2013 Jul 22;3(1):54. doi: 10.1186/2191-219X-3-54. PubMed PMID: 23870677; PubMed Central PMCID: PMC3751550. 19: Klakotskaia D, Ramsey AK, Fowler SW, Serfozo P, Simonyi A, Schachtman TR. Effects of group II and III metabotropic glutamate receptor ligands on conditioned taste aversion learning. Behav Brain Res. 2013 Sep 15;253:9-16. doi: 10.1016/j.bbr.2013.06.032. PubMed PMID: 23827202. 20: Fendt M, Imobersteg S, Peterlik D, Chaperon F, Mattes C, Wittmann C, Olpe HR, Mosbacher J, Vranesic I, van der Putten H, McAllister KH, Flor PJ, Gee CE. Differential roles of mGlu(7) and mGlu(8) in amygdala-dependent behavior and physiology. Neuropharmacology. 2013 Sep;72:215-23. doi: 10.1016/j.neuropharm.2013.04.052. PubMed PMID: 23664812.