Synonym
Vintoperol, RGH-2981, RT-3003, RGH2981, RT3003, RGH 2981, RT 3003
IUPAC/Chemical Name
((1S,12bS)-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-1-yl)methanol
InChi Key
BKRBRZLECKMEBD-QZTJIDSGSA-N
InChi Code
InChI=1S/C18H24N2O/c1-2-18(12-21)9-5-10-20-11-8-14-13-6-3-4-7-15(13)19-16(14)17(18)20/h3-4,6-7,17,19,21H,2,5,8-12H2,1H3/t17-,18-/m1/s1
SMILES Code
CC[C@]1(CO)CCCN2[C@@H]1C3=C(C4=CC=CC=C4N3)CC2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
284.40
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Yoshitsugu H, Fukuhara T, Ishibashi M, Nanbo T, Kagi N. Key fragments for identification of positional isomer pair in glucuronides from the hydroxylated metabolites of RT-3003 (Vintoperol) by liquid chromatography/electrospray ionization mass spectrometry. J Mass Spectrom. 1999 Oct;34(10):1063-8. PubMed PMID: 10510429.
2: Csomor K, Kárpáti E. Effect of vintoperol on platelet aggregation and experimental thrombosis. Arzneimittelforschung. 1994 Jan;44(1):36-40. PubMed PMID: 8135876.
3: Tkachenko MN, Sagach VF, Bazilyuk OV, Shapoval MV. Involvement of endothelium in vasodilating effects of vintoperol. J Cardiovasc Pharmacol. 1992;20 Suppl 12:S90-3. PubMed PMID: 1282997.
4: Sahach VF, Tkachenko MM, Bazyliuk OV. [The role of the endothelium in the vascular effects of vintoperol]. Fiziol Zh. 1992 May-Jun;38(3):32-9. Ukrainian. PubMed PMID: 1499759.
5: Xu R, Liu N, Xu X, Kong B. Antioxidative effects of whey protein on peroxide-induced cytotoxicity. J Dairy Sci. 2011 Aug;94(8):3739-46. doi: 10.3168/jds.2010-3891. PubMed PMID: 21787910.
6: Szombathelyi Z, Kárpáti E, Kalaus G, Szabó L, Szántay C. Vasodilator and angioprotective activity of 1-ethyl-1-hydroxyalkyl-octahydroindolo[2,3a]quinolizine derivates. Arzneimittelforschung. 1991 Jun;41(6):621-5. PubMed PMID: 1930350.
7: Kárpáti E, Bíró K, Kukorelli T. [Investigation of vasoactive agents with indole skeletons at Richter Ltd]. Acta Pharm Hung. 2002;72(1):25-36. Hungarian. PubMed PMID: 12426785.
8: Kaburagi T, Yoshitsugu H, Uekusa H, Ishibashi M, Nanbo T. Identification and clearance involved in the formation of glucuronides of RT-3003, a new peripheral blood flow enhancer, and its metabolite in rats. Biol Pharm Bull. 2000 Jan;23(1):128-31. PubMed PMID: 10706427.
9: Szombathelyi Z, Kárpáti E, Till A. Comparative in vitro study of RGH-2981, a new peripheral blood flow enhancer on animal and pathological human arteries. Pol J Pharmacol Pharm. 1989 Nov-Dec;41(6):591-5. PubMed PMID: 2485906.
