MedKoo Cat#: 530361 | Name: DL 071-IT hydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

DL 071-IT is a potent non-selective beta-adrenoceptor antagonist. DL 071 IT showed intrinsic sympathomimetic activity and weak membrane stabilizing activity. As compared to oxprenolol, DL 071 IT has a longer duration of action and is from 5.0 to 13.5 times more potent.

Chemical Structure

DL 071-IT hydrochloride
DL 071-IT hydrochloride
CAS#55104-39-7

Theoretical Analysis

MedKoo Cat#: 530361

Name: DL 071-IT hydrochloride

CAS#: 55104-39-7

Chemical Formula: C15H22ClNO4

Exact Mass: 0.0000

Molecular Weight: 315.79

Elemental Analysis: C, 57.05; H, 7.02; Cl, 11.23; N, 4.44; O, 20.27

Price and Availability

Size Price Availability Quantity
1g USD 3,250.00 2 Weeks
2g USD 5,250.00 2 Weeks
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Related CAS #
No Data
Synonym
DL071-IT; DL-071-IT; DL 071-IT; DL 071-IT HCl; DL 071-IT hydrochloride, Afurolol HCl;
IUPAC/Chemical Name
1(3H)-Isobenzofuranone, 7-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-, hydrochloride
InChi Key
KTIQCDLYPPAYBF-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H21NO4.ClH/c1-15(2,3)16-7-11(17)9-19-12-6-4-5-10-8-20-14(18)13(10)12;/h4-6,11,16-17H,7-9H2,1-3H3;1H
SMILES Code
O=C1OCC2=C1C(OCC(O)CNC(C)(C)C)=CC=C2.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
DL 071-IT is a potent non-selective beta-adrenoceptor antagonist.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 315.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Marchetti G, Di Francesco GF, Baldoli E. [Effects of a new beta-blocking drug, DL 071-IT, on the myocardial contractile state in the waking dog; a comparison with 9 known beta blockaders]. Boll Soc Ital Cardiol. 1979;24(9):1039-43. Italian. PubMed PMID: 45253. 2: Radice M, Amanzio R, Criscuolo D. Pharmacodynamic studies in man of the beta-adrenoceptor antagonist DL 071 IT. Eur J Clin Pharmacol. 1979 Sep;16(2):87-90. PubMed PMID: 40801.