Synonym
ATUX-1215; ATUX1215; ATUX 1215
IUPAC/Chemical Name
N-(2-(2,8-difluoro-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl)tetrahydro-2H-pyran-4-yl)-4-(trifluoromethoxy)benzenesulfonamide
InChi Key
GQZUAINHIWKUPH-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H24F5NO4S/c28-18-3-9-23-16(13-18)1-2-17-14-19(29)4-10-24(17)26(23)25-15-20(11-12-36-25)33-38(34,35)22-7-5-21(6-8-22)37-27(30,31)32/h3-10,13-14,20,25-26,33H,1-2,11-12,15H2
SMILES Code
O=S(NC1CC(OCC1)C2C3=CC=C(F)C=C3CCC4=CC(F)=CC=C42)(C5=CC=C(C=C5)OC(F)(F)F)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
553.54
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Pillai M, Lafortune P, Dabo A, Yu H, Park SS, Taluru H, Ahmed H, Bobrow D,
Sattar Z, Jundi B, Reece J, Ortega RR, Soto B, Yewedalsew S, Foronjy R, Wyman A,
Geraghty P, Ohlmeyer M. Small-Molecule Activation of Protein Phosphatase 2A
Counters Bleomycin-Induced Fibrosis in Mice. ACS Pharmacol Transl Sci. 2023 Oct
17;6(11):1659-1672. doi: 10.1021/acsptsci.3c00117. PMID: 37974628; PMCID:
PMC10644462.
2: Nazam N, Erwin MH, Julson JR, Quinn CH, Beierle AM, Bownes LV, Stewart JE,
Kang KD, Butey S, Mroczek-Musulman E, Ohlmeyer M, Beierle EA. PP2A activation
overcomes leptomeningeal dissemination in group 3 medulloblastoma. J Biol Chem.
2024 Nov;300(11):107892. doi: 10.1016/j.jbc.2024.107892. Epub 2024 Oct 16. PMID:
39419284; PMCID: PMC11650719.
