Y-26763 | CAS#127408-31-5 | KATP channel activator

MedKoo Cat#: 530442 | Name: Y-26763

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Y-26763 is Kir6 (KATP) channel opener and active metabolite of Y-27152. Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels. Y-26763 protects the working rat myocardium from ischemia/reperfusion injury through opening of KATP channels. Y-26763 activated K(ATP) channels in a reversible manner with a similar activity to diazoxide. Y-26763-induced inhibition of insulin release is dependent upon the activation of K(ATP) channels in human beta-cells.

Chemical Structure

Y-26763

CAS#127408-31-5

Theoretical Analysis

MedKoo Cat#: 530442

Name: Y-26763

CAS#: 127408-31-5

Chemical Formula: C14H16N2O4

Exact Mass: 276.1110

Molecular Weight: 276.29

Elemental Analysis: C, 60.86; H, 5.84; N, 10.14; O, 23.16

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 550.00	2 Weeks
50mg	USD 1,450.00	2 Weeks

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Related CAS #

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Synonym

Y-26763; Y 26763; Y26763.

IUPAC/Chemical Name

N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-hydroxyacetamide

InChi Key

IWTCFIIOUXJOOV-OLZOCXBDSA-N

InChi Code

InChI=1S/C14H16N2O4/c1-8(17)16(19)12-10-6-9(7-15)4-5-11(10)20-14(2,3)13(12)18/h4-6,12-13,18-19H,1-3H3/t12-,13+/m1/s1

SMILES Code

CC(N([C@H]1[C@H](O)C(C)(C)OC2=CC=C(C#N)C=C12)O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 276.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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PMID: 23704088; PMCID: PMC4046169. 4: Shirao S, Fujisawa H, Kudo A, Kurokawa T, Yoneda H, Kunitsugu I, Ogasawara K, Soma M, Kobayashi S, Ogawa A, Suzuki M. Inhibitory effects of eicosapentaenoic acid on chronic cerebral vasospasm after subarachnoid hemorrhage: possible involvement of a sphingosylphosphorylcholine-rho-kinase pathway. Cerebrovasc Dis. 2008;26(1):30-7. doi: 10.1159/000135650. Epub 2008 May 30. PMID: 18511869. 5: Fujimoto S, Mori M, Tsushima H, Kunimatsu M. Capsaicin-induced, capsazepine- insensitive relaxation of the guinea-pig ileum. Eur J Pharmacol. 2006 Jan 13;530(1-2):144-51. doi: 10.1016/j.ejphar.2005.11.011. Epub 2005 Dec 19. PMID: 16360146. 6: Cosgrove KE, Straub SG, Barnes PD, Chapman J, Sharp GW, Dunne MJ. Y-26763: ATP-sensitive K+ channel activation and the inhibition of insulin release from human pancreatic beta-cells. Eur J Pharmacol. 2004 Feb 20;486(2):133-9. doi: 10.1016/j.ejphar.2003.12.017. PMID: 14975702. 7: Hashitani H, Brading AF, Suzuki H. 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Potassium channels activated in the endothelium-dependent hyperpolarization in guinea-pig coronary artery. J Physiol. 1998 Jul 15;510 ( Pt 2)(Pt 2):455-65. doi: 10.1111/j.1469-7793.1998.455bk.x. PMID: 9705996; PMCID: PMC2231052. 18: Doi K, Nagao T, Kawakubo K, Ibayashi S, Aoyagi K, Yano Y, Yamamoto C, Kanamoto K, Iida M, Sadoshima S, Fujishima M. Calcitonin gene-related peptide affords gastric mucosal protection by activating potassium channel in Wistar rat. Gastroenterology. 1998 Jan;114(1):71-6. doi: 10.1016/s0016-5085(98)70634-1. PMID: 9428220. 19: Takaba H, Nagao T, Yao H, Kitazono T, Ibayashi S, Fujishima M. An ATP- sensitive potassium channel activator reduces infarct volume in focal cerebral ischemia in rats. Am J Physiol. 1997 Aug;273(2 Pt 2):R583-6. doi: 10.1152/ajpregu.1997.273.2.R583. PMID: 9277542. 20: Okada H, Kobayashi S, Ikeda T. [Protection afforded by a novel K channel opener (Y-26763), against glycerol-induced acute renal failure (ARF) in rats]. 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