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MedKoo Cat#: 585448 | Name: XM 323

Description:

WARNING: This product is for research use only, not for human or veterinary use.

XM 323 is an inhibitor of clinical isolates of HIV-1 in vitro and represents a novel class of non-peptidyl inhibitors of HIV-1 protease.

Chemical Structure

XM 323
XM 323
CAS#152344-10-0

Theoretical Analysis

MedKoo Cat#: 585448

Name: XM 323

CAS#: 152344-10-0

Chemical Formula: C35H38N2O5

Exact Mass: 566.2781

Molecular Weight: 566.70

Elemental Analysis: C, 74.18; H, 6.76; N, 4.94; O, 14.12

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
XM 323; XM323; XM-323
IUPAC/Chemical Name
2H-1,3-Diazepin-2-one, hexahydro-5,6-dihydroxy-1,3-bis((4-(hydroxymethyl)phenyl)methyl)-4,7-bis(phenylmethyl)-, (4S-(4alpha,5alpha,6beta,7beta))-
InChi Key
XCVGQMUMMDXKCY-PSWJWLENSA-N
InChi Code
InChI=1S/C35H38N2O5/c38-23-29-15-11-27(12-16-29)21-36-31(19-25-7-3-1-4-8-25)33(40)34(41)32(20-26-9-5-2-6-10-26)37(35(36)42)22-28-13-17-30(24-39)18-14-28/h1-18,31-34,38-41H,19-24H2/t31-,32-,33+,34+/m0/s1
SMILES Code
O=C1N(CC2=CC=C(CO)C=C2)[C@@H](CC3=CC=CC=C3)[C@@H](O)[C@H](O)[C@H](CC4=CC=CC=C4)N1CC5=CC=C(CO)C=C5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 566.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Medina DJ, Tung PP, Nelson CJ, Sathya B, Casareale D, Strair RK. Characterization and use of a recombinant retroviral system for the analysis of drug resistant HIV. J Virol Methods. 1998 Apr;71(2):169-76. PubMed PMID: 9626950. 2: Winslow DL, Mayers D, Scarnati H, Lane J, Bincsik A, Otto MJ. In vitro susceptibility of clinical isolates of HIV-1 to XM323, a non-peptidyl HIV protease inhibitor. AIDS. 1994 Jun;8(6):753-6. PubMed PMID: 8086132. 3: Otto MJ, Reid CD, Garber S, Lam PY, Scarnati H, Bacheler LT, Rayner MM, Winslow DL. In vitro anti-human immunodeficiency virus (HIV) activity of XM323, a novel HIV protease inhibitor. Antimicrob Agents Chemother. 1993 Dec;37(12):2606-11. PubMed PMID: 8109924; PubMed Central PMCID: PMC192753.