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MedKoo Cat#: 531359 | Name: A61603

Description:

WARNING: This product is for research use only, not for human or veterinary use.

A61603 is an alpha-1A adrenergic receptor.

Chemical Structure

A61603
A61603
CAS#750531-54-5

Theoretical Analysis

MedKoo Cat#: 531359

Name: A61603

CAS#: 750531-54-5

Chemical Formula: C14H19N3O3S

Exact Mass: 309.1147

Molecular Weight: 309.38

Elemental Analysis: C, 54.35; H, 6.19; N, 13.58; O, 15.51; S, 10.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
107756-30-9 (HBr) 750531-54-5 (free base)
Synonym
A61603
IUPAC/Chemical Name
N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide
InChi Key
OQFCXJDXHCDLHX-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H19N3O3S/c1-21(19,20)17-13-10-3-2-4-11(14-15-7-8-16-14)9(10)5-6-12(13)18/h5-6,11,17-18H,2-4,7-8H2,1H3,(H,15,16)
SMILES Code
CS(=O)(NC1=C2CCCC(C3=NCCN3)C2=CC=C1O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 309.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Dopamine D₁-like receptors regulate the α₁A-adrenergic receptor in human renal proximal tubule cells and D₁-like dopamine receptor knockout mice. Am J Physiol Renal Physiol. 2014 Dec 1;307(11):F1238-48. doi: 10.1152/ajprenal.00119.2014. PubMed PMID: 25339698; PubMed Central PMCID: PMC4254972. 8: Yoshiki H, Uwada J, Umada H, Kobayashi T, Takahashi T, Yamakawa T, Yamaguchi A, Yokoyama O, Muramatsu I. Agonist pharmacology at recombinant α1A - and α1L -adrenoceptors and in lower urinary tract α1 -adrenoceptors. Br J Pharmacol. 2013 Nov;170(6):1242-52. doi: 10.1111/bph.12403. PubMed PMID: 24024968; PubMed Central PMCID: PMC3838699. 9: Amirak E, Fuller SJ, Sugden PH, Clerk A. p90 ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to G(q)-protein-coupled receptor stimuli, endothelin-1 and α(1)-adrenergic receptor agonists. Biochem J. 2013 Mar 1;450(2):351-63. doi: 10.1042/BJ20121371. PubMed PMID: 23215897; PubMed Central PMCID: PMC3573779. 10: Moro C, Tajouri L, Chess-Williams R. Adrenoceptor function and expression in bladder urothelium and lamina propria. Urology. 2013 Jan;81(1):211.e1-7. doi: 10.1016/j.urology.2012.09.011. PubMed PMID: 23200975. 11: Martínez-Salas SG, Campos-Peralta JM, Pardo JP, Hernández-Muñoz R, Ibarra M, Tanoue A, Tsujimoto G, Villalobos-Molina R. α(1D)-Adrenoceptor regulates the vasopressor action of α(1A)-adrenoceptor in mesenteric vascular bed of α(1D)-adrenoceptor knockout mice. Auton Autacoid Pharmacol. 2011 Jul-Oct;31(3-4):64-71. doi: 10.1111/j.1474-8673.2011.00468.x. PubMed PMID: 21951586. 12: Rank MM, Murray KC, Stephens MJ, D'Amico J, Gorassini MA, Bennett DJ. Adrenergic receptors modulate motoneuron excitability, sensory synaptic transmission and muscle spasms after chronic spinal cord injury. J Neurophysiol. 2011 Jan;105(1):410-22. doi: 10.1152/jn.00775.2010. PubMed PMID: 21047936; PubMed Central PMCID: PMC3023364. 13: Evans BA, Broxton N, Merlin J, Sato M, Hutchinson DS, Christopoulos A, Summers RJ. Quantification of functional selectivity at the human α(1A)-adrenoceptor. Mol Pharmacol. 2011 Feb;79(2):298-307. doi: 10.1124/mol.110.067454. Erratum in: Mol Pharmacol. 2011 Mar;79(3):627. PubMed PMID: 20978120. 14: Copik AJ, Ma C, Kosaka A, Sahdeo S, Trane A, Ho H, Dietrich PS, Yu H, Ford AP, Button D, Milla ME. Facilitatory interplay in alpha 1a and beta 2 adrenoceptor function reveals a non-Gq signaling mode: implications for diversification of intracellular signal transduction. Mol Pharmacol. 2009 Mar;75(3):713-28. doi: 10.1124/mol.108.050765. PubMed PMID: 19109357. 15: Mills K, Hausman N, Chess-Williams R. Characterization of the alpha1-adrenoceptor subtype mediating contractions of the pig internal anal sphincter. Br J Pharmacol. 2008 Sep;155(1):110-7. doi: 10.1038/bjp.2008.217. PubMed PMID: 18516067; PubMed Central PMCID: PMC2527848. 16: O-Uchi J, Sasaki H, Morimoto S, Kusakari Y, Shinji H, Obata T, Hongo K, Komukai K, Kurihara S. Interaction of alpha1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel. Circ Res. 2008 Jun 6;102(11):1378-88. doi: 10.1161/CIRCRESAHA.107.167734. PubMed PMID: 18467629. 17: Rojas Gomez DM, Schulte JS, Mohr FW, Dhein S. Alpha-1-adrenoceptor subtype selective regulation of connexin 43 expression in rat cardiomyocytes. Naunyn Schmiedebergs Arch Pharmacol. 2008 Mar;377(1):77-85. doi: 10.1007/s00210-007-0244-9. PubMed PMID: 18193202. 18: Luo DL, Gao J, Fan LL, Tang Y, Zhang YY, Han QD. Receptor subtype involved in alpha 1-adrenergic receptor-mediated Ca2+ signaling in cardiomyocytes. Acta Pharmacol Sin. 2007 Jul;28(7):968-74. PubMed PMID: 17588332. 19: Martínez-Salas SG, Campos-Peralta JM, Pares-Hipolito J, Gallardo-Ortíz IA, Ibarra M, Villalobos-Molina R. Alpha1A-adrenoceptors predominate in the control of blood pressure in mouse mesenteric vascular bed. Auton Autacoid Pharmacol. 2007 Jul;27(3):137-42. PubMed PMID: 17584443. 20: Mehrotra S, Gupta S, Centurión D, Villalón CM, Saxena PR, VandenBrink AM. A61603-induced contractions of the porcine meningeal artery are mediated by alpha1- and alpha2-adrenoceptors. Basic Clin Pharmacol Toxicol. 2007 Apr;100(4):279-85. PubMed PMID: 17371533.