MedKoo Cat#: 531341 | Name: ZCL-278
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ZCL-278 is a small-molecule inhibitor that selectively targets Cdc42, a Rho GTPase involved in cytoskeletal organization and cell signaling. It disrupts Cdc42 interactions with its guanine nucleotide exchange factors (GEFs), affecting cell migration and actin dynamics. ZCL-278 has been studied for its potential in cancer and neurobiology research.

Chemical Structure

ZCL-278
ZCL-278
CAS#587841-73-4

Theoretical Analysis

MedKoo Cat#: 531341

Name: ZCL-278

CAS#: 587841-73-4

Chemical Formula: C21H19BrClN5O4S2

Exact Mass: 582.9750

Molecular Weight: 584.89

Elemental Analysis: C, 43.12; H, 3.27; Br, 13.66; Cl, 6.06; N, 11.97; O, 10.94; S, 10.96

Price and Availability

Size Price Availability Quantity
50mg USD 450.00 2 Weeks
100mg USD 850.00 2 Weeks
200mg USD 1,450.00 2 Weeks
500mg USD 2,950.00 2 Weeks
1g USD 3,850.00 2 Weeks
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Related CAS #
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Synonym
ZCL-278; ZCL 278; ZCL278.
IUPAC/Chemical Name
2-(4-bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]-acetamide
InChi Key
XKZDWYDHEBCGCG-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H19BrClN5O4S2/c1-12-9-13(2)25-20(24-12)28-34(30,31)16-6-4-15(5-7-16)26-21(33)27-19(29)11-32-18-8-3-14(22)10-17(18)23/h3-10H,11H2,1-2H3,(H,24,25,28)(H2,26,27,29,33)
SMILES Code
O=C(NC(NC1=CC=C(S(=O)(NC2=NC(C)=CC(C)=N2)=O)C=C1)=S)COC3=CC=C(Br)C=C3Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 584.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Zhang Q, Qin Z, Wang Q, Lu L, Wang J, Lu M, Wang P, Liu D, Zhou C, Liu Z. Pharmacokinetic profiling of ZCL-278, a cdc42 inhibitor, and its effectiveness against chronic kidney disease. Biomed Pharmacother. 2024 Oct;179:117329. doi: 10.1016/j.biopha.2024.117329. Epub 2024 Aug 24. PMID: 39180793.