UR-1505 | CAS#651331-92-9 | Nuclear Factor of T-cell Inhibitor

MedKoo Cat#: 530103 | Name: UR-1505

Description:

WARNING: This product is for research use only, not for human or veterinary use.

UR-1505 is a nuclear factor of activated T cells (NF-AT) inhibitor potentially for the treatment of atopic dermatitis. UR-1505 acts by means of a specific mechanism inhibiting T cell activation depending on T cell receptor signaling pathway. Furthermore, the antiproliferative effects of UR-1505 are not a consequence of decreased cell viability.

Chemical Structure

UR-1505

CAS#651331-92-9

Theoretical Analysis

MedKoo Cat#: 530103

Name: UR-1505

CAS#: 651331-92-9

Chemical Formula: C10H7F5O4

Exact Mass: 286.0264

Molecular Weight: 286.15

Elemental Analysis: C, 41.97; H, 2.47; F, 33.20; O, 22.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

UR-1505, UR1505, UR 1505

IUPAC/Chemical Name

2-hydroxy-4-(2,2,3,3,3-pentafluoropropoxy)benzoic Acid

InChi Key

BLEWPNAUDGZWPU-UHFFFAOYSA-N

InChi Code

InChI=1S/C10H7F5O4/c11-9(12,10(13,14)15)4-19-5-1-2-6(8(17)18)7(16)3-5/h1-3,16H,4H2,(H,17,18)

SMILES Code

O=C(O)C1=CC=C(OCC(F)(F)C(F)(F)F)C=C1O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 286.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Vives R, Pontes C, Sarasa M, Millier A. Safety and Activity of UR-1505 in Atopic Dermatitis: A Randomized, Double-blind Phase II Exploratory Trial. Clin Ther. 2015 Sep 1;37(9):1955-65. doi: 10.1016/j.clinthera.2015.06.005. PubMed PMID: 26163200. 2: Román J, de Arriba AF, Barrón S, Michelena P, Giral M, Merlos M, Bailón E, Comalada M, Gálvez J, Zarzuelo A, Ramis I. UR-1505, a new salicylate, blocks T cell activation through nuclear factor of activated T cells. Mol Pharmacol. 2007 Aug;72(2):269-79. PubMed PMID: 17475810. 3: Bailón E, Román J, Ramis I, Michelena P, Balsa D, Merlos M, Zarzuelo A, Gálvez J, Comalada M. The new salicylate derivative UR-1505 modulates the Th2/humoral response in a dextran sodium sulphate model of colitis that resembles ulcerative colitis. J Pharmacol Sci. 2009 Feb;109(2):315-8. PubMed PMID: 19234369. 4: Bailón E, Comalada M, Román J, Michelena P, Ramis I, Merlos M, Nieto A, Concha A, Zarzuelo A, Gálvez J. UR-1505, a salicylate able to selectively block T-cell activation, shows intestinal anti-inflammatory activity in the chronic phase of the DSS model of rat colitis. Inflamm Bowel Dis. 2008 Jul;14(7):888-97. doi: 10.1002/ibd.20381. PubMed PMID: 18253952. 5: Bailón E, Camuesco D, Nieto A, Concha A, Fernández de Arriba A, Román J, Ramis I, Merlos M, Zarzuelo A, Gálvez J, Comalada M. The intestinal anti-inflammatory effects of the novel agent UR-1505 in the TNBS model of rat colitis are mediated by T-lymphocyte inhibition. Biochem Pharmacol. 2007 Nov 15;74(10):1496-506. PubMed PMID: 17720145.