RWJ-445167 is a dual FIIa/Xa inhibitor.
MedKoo Cat#: 129058
Name: RWJ-445167
CAS#: 226566-43-4
Chemical Formula: C18H24N6O5S
Exact Mass: 436.1500
Molecular Weight: 436.49
Elemental Analysis: C, 49.53; H, 5.54; N, 19.25; O, 18.33; S, 7.35
The following data is based on the product molecular weight 436.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Maryanoff BE, McComsey DF, Costanzo MJ, Yabut SC, Lu T, Player MR, Giardino
EC, Damiano BP. Exploration of potential prodrugs of RWJ-445167, an
oxyguanidine-based dual inhibitor of thrombin and factor Xa. Chem Biol Drug Des.
2006 Jul;68(1):29-36. doi: 10.1111/j.1747-0285.2006.00408.x. PMID: 16923023.
2: Dai WG, Dong LC, Song Y. Enhanced bioavailability of poorly absorbed
hydrophilic compounds through drug complex/in situ gelling formulation. Int J
Pharm. 2013 Nov 30;457(1):63-70. doi: 10.1016/j.ijpharm.2013.07.066. Epub 2013
Sep 1. PMID: 24004566.
3: Giardino EC, Haertlein BJ, de Garavilla L, Costanzo MJ, Damiano BP, Andrade-
Gordon P, Maryanoff BE. Cooperative antithrombotic effect from the simultaneous
inhibition of thrombin and factor Xa. Blood Coagul Fibrinolysis. 2010
Mar;21(2):128-34. doi: 10.1097/MBC.0b013e3283358100. PMID: 20010091.
