Radequinil| AC-3933| CAS#219846-31-8| GABA receptor| benzodiazepine| MedKoo

MedKoo Cat#: 530223 | Name: Radequinil

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Radequinil, also known as AC-3933, is a novel benzodiazepine GABA receptor inverse agonist potentially for the treatment of Alzheimer's disease. It is shown to have a procognitive effect of AC-3933 in aged mice, and synergistic effect of combination with donepezil in scopolamine-treated mice.

Chemical Structure

Radequinil

CAS#219846-31-8

Theoretical Analysis

MedKoo Cat#: 530223

Name: Radequinil

CAS#: 219846-31-8

Chemical Formula: C18H14N4O3

Exact Mass: 334.1066

Molecular Weight: 334.34

Elemental Analysis: C, 64.67; H, 4.22; N, 16.76; O, 14.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Radequinil; AC-3933; AVE-3933; SX-3933; AC3933; AVE3933; SX3933; AC 3933; AVE 3933; SX 3933

IUPAC/Chemical Name

5-(3-methoxyphenyl)-3-(5-methyl-1,2,4-oxadiazol-3-yl)-1,6-naphthyridin-2(1H)-one

InChi Key

JQOFKKWHXGQABB-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H14N4O3/c1-10-20-17(22-25-10)14-9-13-15(21-18(14)23)6-7-19-16(13)11-4-3-5-12(8-11)24-2/h3-9H,1-2H3,(H,21,23)

SMILES Code

O=C1NC2=C(C(C3=CC=CC(OC)=C3)=NC=C2)C=C1C4=NOC(C)=N4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 334.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Hashimoto T, Hatayama Y, Nakamichi K, Yoshida N. Procognitive effect of AC-3933 in aged mice, and synergistic effect of combination with donepezil in scopolamine-treated mice. Eur J Pharmacol. 2014 Dec 15;745:123-8. doi: 10.1016/j.ejphar.2014.10.015. PubMed PMID: 25446931. 2: Hashimoto T, Iwamura Y. AC-3933, a benzodiazepine partial inverse agonist, improves memory performance in MK-801-induced amnesia mouse model. Pharmacol Biochem Behav. 2016 May;144:45-52. doi: 10.1016/j.pbb.2016.03.001. PubMed PMID: 26946254. 3: Hatayama Y, Hashimoto T, Kohayakawa H, Kiyoshi T, Nakamichi K, Kinoshita T, Yoshida N. In vivo pharmacological characterization of AC-3933, a benzodiazepine receptor partial inverse agonist for the treatment of Alzheimer's disease. Neuroscience. 2014 Apr 18;265:217-25. doi: 10.1016/j.neuroscience.2014.01.063. PubMed PMID: 24513386. 4: Hashimoto T, Kiyoshi T, Kohayakawa H, Iwamura Y, Yoshida N. Pharmacological properties of AC-3933, a novel benzodiazepine receptor partial inverse agonist. Neuroscience. 2014 Jan 3;256:352-9. PubMed PMID: 24505610. 5: Mise M, Yadera S, Matsuda M, Hashizume T, Matsumoto S, Terauchi Y, Fujii T. Polymorphic expression of CYP1A2 leading to interindividual variability in metabolism of a novel benzodiazepine receptor partial inverse agonist in dogs. Drug Metab Dispos. 2004 Feb;32(2):240-5. PubMed PMID: 14744947. 6: Mise M, Hashizume T, Matsumoto S, Terauchi Y, Fujii T. Identification of non-functional allelic variant of CYP1A2 in dogs. Pharmacogenetics. 2004 Nov;14(11):769-73. PubMed PMID: 15564884.