MedKoo Cat#: 145759 | Name: SQ-11447

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SQ-11447 is a selective inhibitor of the enzyme acetyl-CoA carboxylase (ACC), which plays a key role in fatty acid metabolism. By inhibiting ACC, SQ-11447 may help regulate lipid metabolism and has been investigated for potential therapeutic applications in conditions like obesity, non-alcoholic fatty liver disease (NAFLD), and other metabolic disorders. Its action on ACC could influence the synthesis of fatty acids and impact fat storage, potentially offering benefits in managing metabolic diseases.

Chemical Structure

SQ-11447
SQ-11447
CAS#33406-68-7

Theoretical Analysis

MedKoo Cat#: 145759

Name: SQ-11447

CAS#: 33406-68-7

Chemical Formula: C13H21N3OS

Exact Mass: 267.1400

Molecular Weight: 267.39

Elemental Analysis: C, 58.40; H, 7.92; N, 15.72; O, 5.98; S, 11.99

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
SQ-11447; SQ11447; SQ 11447;
IUPAC/Chemical Name
1-(2-((3-(dimethylamino)propyl)thio)phenyl)-3-methylurea
InChi Key
LNAUGIJFFGNNRW-UHFFFAOYSA-N
InChi Code
1S/C13H21N3OS/c1-14-13(17)15-11-7-4-5-8-12(11)18-10-6-9-16(2)3/h4-5,7-8H,6,9-10H2,1-3H3,(H2,14,15,17)
SMILES Code
CNC(=O)NC1=C(SCCCN(C)C)C=CC=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 267.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wong KK, Dreyfuss J, Schreiber EC. In vitro metabolism of dimethylaminopropylthio-cinnamanilide (SQ 16,167) and its methylureido analogue (SQ 11,447). Xenobiotica. 1971 Jan;1(1):25-7. doi: 10.3109/00498257109044376. PMID: 5163173.