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MedKoo Cat#: 329468 | Name: Eclanamine maleate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Eclanamine, also known as U-48753E, is a potential agent which was subjected to a battery of short-term assays for genetic activity. U-48753E was discovered to be slightly mutagenic in the AS52 assay, and significant efforts were expended in evaluation of the metabolism-based generation of a reactive intermediate.

Chemical Structure

Eclanamine maleate
Eclanamine maleate
CAS#67450-45-7 (maleate)

Theoretical Analysis

MedKoo Cat#: 329468

Name: Eclanamine maleate

CAS#: 67450-45-7 (maleate)

Chemical Formula: C20H26Cl2N2O5

Exact Mass:

Molecular Weight: 445.34

Elemental Analysis: C, 53.94; H, 5.88; Cl, 15.92; N, 6.29; O, 17.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
67450-45-7 (maleate) 67450-44-6 (free base)
Synonym
Eclanamine maleate; U-48,753E; U48,753E; U 48,753E; U-48753E; U48753E; U 48753E.
IUPAC/Chemical Name
N-(3,4-dichlorophenyl)-N-[(1R,2R)-2-(dimethylamino)cyclopentyl]-propanamide maleate
InChi Key
ZEUQHGFLDLNEOB-CHHFXETESA-N
InChi Code
InChI=1S/C16H22Cl2N2O.C4H4O4/c1-4-16(21)20(11-8-9-12(17)13(18)10-11)15-7-5-6-14(15)19(2)3;5-3(6)1-2-4(7)8/h8-10,14-15H,4-7H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,15-;/m1./s1
SMILES Code
CCC(N(C1=CC=C(Cl)C(Cl)=C1)[C@H]2[C@H](N(C)C)CCC2)=O.O=C(O)/C=C\C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Related CAS# CAS#67450-45-7 (Eclanamine maleate) CAS#67450-44-6 (Eclanamine free base)

Preparing Stock Solutions

The following data is based on the product molecular weight 445.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Aaron CS, Harbach PR, Mattano SS, Mayo JK, Wang Y, Yu RL, Zimmer DM. Risk and benefit evaluation in development of pharmaceutical products. Environ Health Perspect. 1993 Oct;101 Suppl 3:291-5. Review. PubMed PMID: 8143634; PubMed Central PMCID: PMC1521120. 2: Aaron CS, Stankowski LF Jr, Harbach PR, Valencia R, Mayo JK, Mirsalis J, Mazurek JH, Steinmetz KL, Wiser SK, Zimmer DM, et al. Comparative mutagenicity testing of a drug candidate, U-48753E: mechanism of induction of gene mutations in mammalian cells and quantitation of potential hazard. Mutat Res. 1989 Jun;223(2):111-20. PubMed PMID: 2500592. 3: Sethy VH, Day JS, Cooper MM. Dose-dependent down-regulation of beta-adrenergic receptors after chronic intravenous infusion of antidepressants. Prog Neuropsychopharmacol Biol Psychiatry. 1988;12(5):673-82. PubMed PMID: 2851860.

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