Sudoxicam | CAS#34042-85-8 | NSAID

MedKoo Cat#: 526370 | Name: Sudoxicam

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sudoxicam is a nonsteroidal anti-inflammatory drugs (NSAIDs) from the enol-carboxamide class.

Chemical Structure

Sudoxicam

CAS#34042-85-8

Theoretical Analysis

MedKoo Cat#: 526370

Name: Sudoxicam

CAS#: 34042-85-8

Chemical Formula: C13H11N3O4S2

Exact Mass: 337.0191

Molecular Weight: 337.37

Elemental Analysis: C, 46.28; H, 3.29; N, 12.46; O, 18.97; S, 19.01

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Synonym

Sudoxicam; CP-15,973; CP 15,973; CP15,973; CP-15973; CP 15973; CP15973; NSC 615046; Normeloxicam;

IUPAC/Chemical Name

4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide

InChi Key

SYCHUQUJURZQMO-UHFFFAOYSA-N

InChi Code

InChI=1S/C13H11N3O4S2/c1-16-10(12(18)15-13-14-6-7-21-13)11(17)8-4-2-3-5-9(8)22(16,19)20/h2-7,17H,1H3,(H,14,15,18)

SMILES Code

O=C(C1=C(O)C2=CC=CC=C2S(N1C)(=O)=O)NC3=NC=CS3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Sudoxicam is a reversible and orally active COX antagonist.

In vitro activity:

To be determined

In vivo activity:

To be determined

Preparing Stock Solutions

The following data is based on the product molecular weight 337.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

To be determined

In vitro protocol:

To be determined

In vivo protocol:

To be determined

1: Obach RS, Kalgutkar AS, Ryder TF, Walker GS. In vitro metabolism and covalent binding of enol-carboxamide derivatives and anti-inflammatory agents sudoxicam and meloxicam: insights into the hepatotoxicity of sudoxicam. Chem Res Toxicol. 2008 Sep;21(9):1890-9. doi: 10.1021/tx800185b. PubMed PMID: 18707140. 2: Hobbs DC, Twomey TM. Metabolism of sudoxicam by the rat, dog, and monkey. Drug Metab Dispos. 1977 Jan-Feb;5(1):75-81. PubMed PMID: 13979. 3: Wiseman EH, Chang YH, Hobbs DC. Interaction of sudoxicam and aspirin in animals and man. Clin Pharmacol Ther. 1975 Oct;18(4):441-8. PubMed PMID: 809225. 4: Constantine JW, Purcell IM. Inhibition of platelet aggregation and of experimental thrombosis by sudoxicam. J Pharmacol Exp Ther. 1973 Dec;187(3):653-65. PubMed PMID: 4770405. 5: Wiseman EH, Chiaini J. Anti-inflammatory and pharmacokinetic properties of sudoxicam N-(2-thiazolyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide. Biochem Pharmacol. 1972 Sep 1;21(17):2323-34. PubMed PMID: 4630489. 6: Lombardino JG, Wiseman EH. Sudoxicam and related N-heterocyclic carboxamides of 4-hydroxy-2H-1,2-benzothiazine 1,1-dioxide. Potent nonsteroidal antiinflammatory agents. J Med Chem. 1972 Aug;15(8):848-9. PubMed PMID: 4625532.