Intepirdine | SB742457 | RVT-101 | CAS#607742-69-8 | 5-HT6 receptor antagonist

MedKoo Cat#: 522418 | Name: Intepirdine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Intepirdine, also known as SB-742457 and RVT-101, is a selective 5-HT6 receptor antagonist with potential cognition, memory, and learning-enhancing effects. It was under development by GlaxoSmithKline for the treatment of Alzheimer's disease and demonstrated some preliminary efficacy in phase II clinical trials. SB742457 can reverse age-related declines in delayed non-match-to-sample performance (DNMS). SB742457 shows increasing pro-cognitive effects in patients with AD.

Chemical Structure

Intepirdine

CAS#607742-69-8

Theoretical Analysis

MedKoo Cat#: 522418

Name: Intepirdine

CAS#: 607742-69-8

Chemical Formula: C19H19N3O2S

Exact Mass: 353.1198

Molecular Weight: 353.44

Elemental Analysis: C, 64.57; H, 5.42; N, 11.89; O, 9.05; S, 9.07

Price and Availability

Size	Price	Availability
25mg	USD 250.00	2 Weeks
50mg	USD 450.00	2 Weeks
100mg	USD 750.00	2 Weeks
200mg	USD 1,250.00	2 Weeks
500mg	USD 2,850.00	2 Weeks

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Related CAS #

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Synonym

SB742457; SB 742457; SB-742457; RVT-101; RVT 101; RVT101. intepirdine.

IUPAC/Chemical Name

3-Phenylsulfonyl-8-(piperazin-1-yl)quinoline

InChi Key

JJZFWROHYSMCMU-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H19N3O2S/c23-25(24,16-6-2-1-3-7-16)17-13-15-5-4-8-18(19(15)21-14-17)22-11-9-20-10-12-22/h1-8,13-14,20H,9-12H2

SMILES Code

O=S(C1=CC2=CC=CC(N3CCNCC3)=C2N=C1)(C4=CC=CC=C4)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Intepirdine (SB742457) is a highly selective 5-HT6 receptor antagonist with pKi of 9.63; exhibits >100-fold selectivity over other receptors.

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMF	5.0	14.15
	DMSO	44.3	125.43
	Ethanol	1.1	2.97

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 353.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.