Sezolamide hydrochloride | CAS# 119271-78-2 | carbonic anhydrase inhibitor

MedKoo Cat#: 526334 | Name: Sezolamide hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sezolamide hydrochloride is a potent topical carbonic anhydrase inhibitor for the study of its ocular hypotensive activity in patients with elevated intraocular pressure.

Chemical Structure

Sezolamide hydrochloride

CAS#119271-78-2

Theoretical Analysis

MedKoo Cat#: 526334

Name: Sezolamide hydrochloride

CAS#: 119271-78-2

Chemical Formula: C11H19ClN2O4S3

Exact Mass:

Molecular Weight: 374.91

Elemental Analysis: C, 35.24; H, 5.11; Cl, 9.46; N, 7.47; O, 17.07; S, 25.65

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Sezolamide hydrochloride; Sezolamide HCl; Sezolamide; MK 417; MK-417.

IUPAC/Chemical Name

(+)-(S)-5,6-Dihydro-4-(isobutylamino)-4H-thieno(2,3-b)thiopyran-2-sulfonamide, 7,7-dioxide, monohydrochloride

InChi Key

VYZDSLFBCSLIEA-FVGYRXGTSA-N

InChi Code

InChI=1S/C11H18N2O4S3.ClH/c1-7(2)6-13-9-3-4-19(14,15)11-8(9)5-10(18-11)20(12,16)17;/h5,7,9,13H,3-4,6H2,1-2H3,(H2,12,16,17);1H/t9-;/m0./s1

SMILES Code

O=S(C(S1)=CC([C@@H](NCC(C)C)CC2)=C1S2(=O)=O)(N)=O.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 374.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Gunning FP, Greve EL, Bron AM, Bosc JM, Royer JG, George JL, Lesure P, Sirbat D. Two topical carbonic anhydrase inhibitors sezolamide and dorzolamide in Gelrite vehicle: a multiple-dose efficacy study. Graefes Arch Clin Exp Ophthalmol. 1993 Jul;231(7):384-8. PubMed PMID: 8406063. 2: Gunning F, Béchetoille A, Lippa EA, Pfeiffer N, Gerling J, Holder D, Clineschmidt C, Buntinx A, Brunner-Ferber FL, Grehn F, et al. Sezolamide: additivity to timolol twice daily. Eye (Lond). 1992;6 ( Pt 5):525-9. PubMed PMID: 1286720. 3: Buclin T, Biollaz J, Lippa EA, Brunner-Ferber F, van Melle G, Munafo A, Clineschmidt C, Schelling JL. Absence of metabolic effects of the topical carbonic anhydrase inhibitors MK-927 and sezolamide during two-week ocular administration to normal subjects. Clin Pharmacol Ther. 1991 Jun;49(6):665-73. PubMed PMID: 2060255. 4: Lippa EA, Schuman JS, Higginbotham EJ, Kass MA, Weinreb RN, Skuta GL, Epstein DL, Shaw B, Holder DJ, Deasy DA, et al. MK-507 versus sezolamide. Comparative efficacy of two topically active carbonic anhydrase inhibitors. Ophthalmology. 1991 Mar;98(3):308-12; discussion 312-3. PubMed PMID: 2023750. 5: Bron A, Lippa EA, Gunning F, Bénichou C, Lesure P, Sirbat D, Royer J, Flament J, Clineschmidt C, Panebianco D, et al. Multiple-dose efficacy comparison of the two topical carbonic anhydrase inhibitors sezolamide and MK-927. Arch Ophthalmol. 1991 Jan;109(1):50-3. PubMed PMID: 1987948. 6: Pfeiffer N, Greve E, Béchetoille A, Lippa EA, Jaquet-Müller F, Gunning F, Gerling J, Grehn F. [Additive effect of timolol and the local carbonic anhydrase inhibitor MK-417 (sezolamide)]. Fortschr Ophthalmol. 1991;88(6):846-7. German. PubMed PMID: 1794818.