GW-813893, also known as GSK-813893, is a potent, selective and orally active factor Xa inhibitor potentially for the treatment of thromboembolism. GW813893 was more than 90-fold selective over all enzymes tested, and it inhibited FXa and prothrombinase activity with a Ki of 4.0 nM and 9.7 nM, respectively. In vivo, GW813893 concentration-dependently suppressed thrombotic activity in all models tested.
MedKoo Cat#: 530414
Name: GW-813893
CAS#: 478644-12-1
Chemical Formula: C17H22ClN3O5S2
Exact Mass: 447.0689
Molecular Weight: 447.95
Elemental Analysis: C, 45.58; H, 4.95; Cl, 7.91; N, 9.38; O, 17.86; S, 14.31
The following data is based on the product molecular weight 447.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
