Synonym
Sch 24518; Sch24518; Sch-24518.
IUPAC/Chemical Name
8-Chloro-2,3,4,5-tetrahydro-5-phenyl-1H-3-benzazepin-7-ol
SMILES Code
OC1=C(Cl)C=C2CCNCC(C3=CC=CC=C3)C2=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
Preparing Stock Solutions
The following data is based on the
product
molecular weight
273.76
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Yang ZY, Perry B, Mukherjee J. Fluorinated benzazepines: 1. Synthesis, radiosynthesis and biological evaluation of a series of substituted benzazepines as potential radiotracers for positron emission tomographic studies of dopamine D-1 receptors. Nucl Med Biol. 1996 Aug;23(6):793-805. PubMed PMID: 8940723.
2: Rinne JO, Laihinen A, Någren K, Bergman J, Solin O, Haaparanta M, Ruotsalainen U, Rinne UK. PET demonstrates different behaviour of striatal dopamine D-1 and D-2 receptors in early Parkinson's disease. J Neurosci Res. 1990 Dec;27(4):494-9. PubMed PMID: 1981915.
3: Ram S, Ehrenkaufer RE, Spicer LD. Synthesis of the labeled D1 receptor antagonist SCH 23390 using [11C]carbon dioxide. Int J Rad Appl Instrum A. 1989;40(5):425-7. PubMed PMID: 2548974.
4: Adam MJ, Grierson JR, Jivan S. An improved HPLC system for the analysis and purification of organic amine radiopharmaceuticals. Int J Rad Appl Instrum A. 1989;40(1):91-2. PubMed PMID: 2540126.
5: DeJesus OT, Van Moffaert GJ, Friedman AM. Synthesis of [11C]SCH 23390 for dopamine D1 receptor studies. Int J Rad Appl Instrum A. 1987;38(5):345-8. PubMed PMID: 3038787.
6: Halldin C, Stone-Elander S, Farde L, Ehrin E, Fasth KJ, Långström B, Sedvall G. Preparation of 11C-labelled SCH 23390 for the in vivo study of dopamine D-1 receptors using positron emission tomography. Int J Rad Appl Instrum A. 1986;37(10):1039-43. PubMed PMID: 3027000.
