DK419 is a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth. DK419 inhibited Wnt/β-catenin signaling, altered cellular oxygen consumption rate and induced production of pAMPK. DK419 inhibited the growth of CRC tumor cells in vitro, had good plasma exposure when dosed orally, and inhibited the growth of patient derived CRC240 tumor explants in mice dosed orally.
MedKoo Cat#: 407952
Name: DK419
CAS#: 2102672-22-8
Chemical Formula: C16H8ClF6N3O
Exact Mass: 407.0260
Molecular Weight: 407.70
Elemental Analysis: C, 47.14; H, 1.98; Cl, 8.70; F, 27.96; N, 10.31; O, 3.92
The following data is based on the product molecular weight 407.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
