Ro 31-8830 | CAS# 131848-98-1

MedKoo Cat#: 526204 | Name: Ro 31-8830

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ro 31-8830 is a derivative of Ro 31-8425 with in vivo anti-inflammatory activity.

Chemical Structure

Ro 31-8830

CAS#131848-98-1

Theoretical Analysis

MedKoo Cat#: 526204

Name: Ro 31-8830

CAS#: 131848-98-1

Chemical Formula: C28H28N4O2

Exact Mass: 452.2212

Molecular Weight: 452.56

Elemental Analysis: C, 74.31; H, 6.24; N, 12.38; O, 7.07

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Ro 31-8830; Ro 318830; Ro-31-8830.

IUPAC/Chemical Name

3-(8-((Dimethylamino)methyl)-6,7,8,9-tetrahydropyrido(1,2-a)indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

InChi Key

FXGHOAZJQNLNFD-UHFFFAOYSA-N

InChi Code

InChI=1S/C28H28N4O2/c1-30(2)15-17-12-13-32-22-11-7-5-9-19(22)24(23(32)14-17)26-25(27(33)29-28(26)34)20-16-31(3)21-10-6-4-8-18(20)21/h4-11,16-17H,12-15H2,1-3H3,(H,29,33,34)

SMILES Code

O=C(C(C1=C(CC(CN(C)C)CC2)N2C3=C1C=CC=C3)=C4C5=CN(C)C6=C5C=CC=C6)NC4=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 452.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Harmon CS, Nevins TD, Ducote J, Lutz D. Bisindolylmaleimide protein-kinase-C inhibitors delay the decline in DNA synthesis in mouse hair follicle organ cultures. Skin Pharmacol. 1997;10(2):71-8. PubMed PMID: 9257375. 2: Hahn M, Lorez H, Fischer G. The immortalized astroglial cell line RC7 is a new model system for the study of nerve growth factor (NGF) regulation: stimulation by interleukin-1 beta and transforming growth factor-beta 1 is additive and affected differently by dibutyryl cyclic AMP. Glia. 1994 Apr;10(4):286-95. PubMed PMID: 8056439. 3: Mulqueen MJ, Bradshaw D, Davis PD, Elliott L, Griffiths TA, Hill CH, Kumar H, Lawton G, Nixon JS, Sedgwick AD, et al. Oral, anti-inflammatory activity of a potent, selective, protein kinase C inhibitor. Agents Actions. 1992 Sep;37(1-2):85-9. PubMed PMID: 1456183. 4: Nixon JS, Bishop J, Bradshaw D, Davis PD, Hill CH, Elliott LH, Kumar H, Lawton G, Lewis EJ, Mulqueen M, et al. The design and biological properties of potent and selective inhibitors of protein kinase C. Biochem Soc Trans. 1992 May;20(2):419-25. Review. PubMed PMID: 1397642. 5: Nixon JS, Bishop J, Bradshaw D, Davis PD, Hill CH, Elliott LH, Kumar H, Lawton G, Lewis EJ, Mulqueen M, et al. Novel, potent and selective inhibitors of protein kinase C show oral anti-inflammatory activity. Drugs Exp Clin Res. 1991;17(8):389-93. PubMed PMID: 1822831.