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MedKoo Cat#: 526963 | Name: ALS-8112 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ALS-8112 drug effective in the clinic against respiratory syncytial virus (RSV) infection. The antiviral activity of ALS-8112 is mediated by its 5'-triphosphate metabolite (ALS-8112-TP, or 2'F-4'ClCH2-cytidine triphosphate) inhibiting the RNA polymerase activity of the RSV L-P protein complex through RNA chain termination.

Chemical Structure

ALS-8112 HCl
ALS-8112 HCl
CAS#ALS-8112 HCl

Theoretical Analysis

MedKoo Cat#: 526963

Name: ALS-8112 HCl

CAS#: ALS-8112 HCl

Chemical Formula: C10H13ClFN3O4

Exact Mass: 293.0579

Molecular Weight: 293.68

Elemental Analysis: C, 40.90; H, 4.46; Cl, 12.07; F, 6.47; N, 14.31; O, 21.79

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1445379-92-9 (free base) ALS-8112 HCl
Synonym
ALS-8112 HCl; ALS 8112 HCl; ALS8112 HCl; ALS-008112 HCl; ALS 008112 HCl; ALS008112 HCl;
IUPAC/Chemical Name
4-amino-1-((2R,3R,4R,5R)-5-(chloromethyl)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one hydrochloride
InChi Key
AZRVBZVLNGUTQN-RZHUFPKKSA-N
InChi Code
InChI=1S/C10H13ClFN3O4.ClH/c11-3-10(4-16)7(17)6(12)8(19-10)15-2-1-5(13)14-9(15)18;/h1-2,6-8,16-17H,3-4H2,(H2,13,14,18);1H/t6-,7+,8-,10-;/m1./s1
SMILES Code
O=C1N=C(N)C=CN1[C@@H]2O[C@@](CO)(CCl)[C@@H](O)[C@H]2F.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 293.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Deval J, Fung A, Stevens SK, Jordan PC, Gromova T, Taylor JS, Hong J, Meng J, Wang G, Dyatkina N, Prhavc M, Symons JA, Beigelman L. Biochemical Effect of Resistance Mutations against Synergistic Inhibitors of RSV RNA Polymerase. PLoS One. 2016 May 10;11(5):e0154097. doi: 10.1371/journal.pone.0154097. PubMed PMID: 27163448; PubMed Central PMCID: PMC4862670. 2: Deval J, Hong J, Wang G, Taylor J, Smith LK, Fung A, Stevens SK, Liu H, Jin Z, Dyatkina N, Prhavc M, Stoycheva AD, Serebryany V, Liu J, Smith DB, Tam Y, Zhang Q, Moore ML, Fearns R, Chanda SM, Blatt LM, Symons JA, Beigelman L. Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate. PLoS Pathog. 2015 Jun 22;11(6):e1004995. doi: 10.1371/journal.ppat.1004995. PubMed PMID: 26098424; PubMed Central PMCID: PMC4476725.