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MedKoo Cat#: 526959 | Name: Thioflosulide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Thioflosulide, also known as L-745337, is a potent, selective, and orally active COX-2 inhibitor potentially for the treatment of inflammation and pain.

Chemical Structure

Thioflosulide
Thioflosulide
CAS#158205-05-1

Theoretical Analysis

MedKoo Cat#: 526959

Name: Thioflosulide

CAS#: 158205-05-1

Chemical Formula: C16H13F2NO3S2

Exact Mass: 369.0305

Molecular Weight: 369.40

Elemental Analysis: C, 52.02; H, 3.55; F, 10.29; N, 3.79; O, 12.99; S, 17.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
L-745337; L 745337; L745337; L-745,337; L 745,337; L745,337. Thioflosulide
IUPAC/Chemical Name
N-(6-((2,4-Difluorophenyl)thio)-2,3-dihydro-1-oxo-1H-inden-5-yl)methanesulfonamide
InChi Key
HDUWKQUHMUSICC-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H13F2NO3S2/c1-24(21,22)19-13-6-9-2-4-14(20)11(9)8-16(13)23-15-5-3-10(17)7-12(15)18/h3,5-8,19H,2,4H2,1H3
SMILES Code
CS(=O)(NC1=CC2=C(C(CC2)=O)C=C1SC3=CC=C(F)C=C3F)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 369.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Contractile effect of anaphylatoxin C5a and of a mimetic peptide on the human umbilical artery: further evidence for leukocyte-dependent vasomotion. J Cardiovasc Pharmacol. 2002 Dec;40(6):815-21. PubMed PMID: 12451314. 9: Kroin JS, Buvanendran A, McCarthy RJ, Hemmati H, Tuman KJ. Cyclooxygenase-2 inhibition potentiates morphine antinociception at the spinal level in a postoperative pain model. Reg Anesth Pain Med. 2002 Sep-Oct;27(5):451-5. PubMed PMID: 12373690. 10: Coceani F, Ackerley C, Seidlitz E, Kelsey L. Function of cyclo-oxygenase-1 and cyclo-oxygenase-2 in the ductus arteriosus from foetal lamb: differential development and change by oxygen and endotoxin. Br J Pharmacol. 2001 Jan;132(1):241-51. PubMed PMID: 11156583; PubMed Central PMCID: PMC1572537. 11: Turull N, Queralt J. Effect of the COX-2 selective inhibitor l-745,337 on inflammation and organ prostaglandin E2 (PGE2) levels in adjuvant arthritic rats. Inflammation. 2000 Dec;24(6):533-45. 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PubMed PMID: 10699967. 15: Patrignani P, Santini G, Sciulli MG, Marinacci R, Fusco O, Spoletini L, Natoli C, Procopio A, Maclouf J. Cyclooxygenase-independent induction of p21WAF-1/CIP1, apoptosis and differentiation by L-745,337 and salicylate in HT-29 colon cancer cells. Adv Exp Med Biol. 1999;469:555-61. PubMed PMID: 10667382. 16: Turull A, Queralt J. Selective cyclooxygenase-2 (COX-2) inhibitors reduce anti-Mycobacterium antibodies in adjuvant arthritic rats. Immunopharmacology. 2000 Jan;46(1):71-7. PubMed PMID: 10665781. 17: McCartney SA, Mitchell JA, Fairclough PD, Farthing MJ, Warner TD. Selective COX-2 inhibitors and human inflammatory bowel disease. Aliment Pharmacol Ther. 1999 Aug;13(8):1115-7. PubMed PMID: 10468690. 18: Jourdan KB, Evans TW, Lamb NJ, Goldstraw P, Mitchell JA. Autocrine function of inducible nitric oxide synthase and cyclooxygenase-2 in proliferation of human and rat pulmonary artery smooth-muscle cells: species variation. Am J Respir Cell Mol Biol. 1999 Jul;21(1):105-10. PubMed PMID: 10385598. 19: Giuliano F, Warner TD. Ex vivo assay to determine the cyclooxygenase selectivity of non-steroidal anti-inflammatory drugs. Br J Pharmacol. 1999 Apr;126(8):1824-30. PubMed PMID: 10372826; PubMed Central PMCID: PMC1565969. 20: Jourdan KB, Evans TW, Goldstraw P, Mitchell JA. Isoprostanes and PGE2 production in human isolated pulmonary artery smooth muscle cells: concomitant and differential release. FASEB J. 1999 Jun;13(9):1025-30. PubMed PMID: 10336884.