Teloxantrone HCl | Moxantrazole | 132937-88-3 | CAS#91141-48-4 | topoisomerase II inhibitor

MedKoo Cat#: 206748 | Name: Teloxantrone HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Teloxantrone, also known as Moxantrazole, CI-937; DuP-937; NSC-355644; PD-113309, is a DNA topoisomerase II inhibitor potentially for the treatment of solid tumors.

Chemical Structure

Teloxantrone HCl

CAS#132937-88-3 (HCl)

Theoretical Analysis

MedKoo Cat#: 206748

Name: Teloxantrone HCl

CAS#: 132937-88-3 (HCl)

Chemical Formula: C21H27Cl2N5O4

Exact Mass: 411.1907

Molecular Weight: 484.38

Elemental Analysis: C, 52.07; H, 5.62; Cl, 14.64; N, 14.46; O, 13.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

132937-88-3 (HCl) 91441-48-4 (free base) 123830-79-5 (HCl)

Synonym

Moxantrazole; Teloxantrone; CI-937; DuP-937; NSC-355644; PD-113309; CI937; DuP937; NSC355644; PD113309.

IUPAC/Chemical Name

7,10-dihydroxy-2-(2-((2-hydroxyethyl)amino)ethyl)-5-((2-(methylamino)ethyl)amino)dibenzo[cd,g]indazol-6(2H)-one dihydrochloride

InChi Key

SZTBQTTVEIEAQV-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H25N5O4.2ClH/c1-22-6-7-24-12-2-3-13-17-16(12)21(30)19-15(29)5-4-14(28)18(19)20(17)25-26(13)10-8-23-9-11-27;;/h2-5,22-24,27-29H,6-11H2,1H3;2*1H

SMILES Code

O=C1C2=C3C(N(CCNCCO)N=C3C4=C(O)C=CC(O)=C14)=CC=C2NCCNC.[H]Cl.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 484.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Armand JP. New anticancer drugs in Europe. Gan To Kagaku Ryoho. 1997 May;24 Suppl 1:70-93. Review. PubMed PMID: 9210890. 2: Gogas H, Mansi JL. New drugs. The anthrapyrazoles. Cancer Treat Rev. 1996 Nov;21(6):541-52. Review. PubMed PMID: 8599804. 3: Renner U, Blanz J, Freund S, Waidelich D, Ehninger G, Zeller KP. Biotransformation of CI-937 in primary cultures of rat hepatocytes. Formation of glutathione conjugates. Drug Metab Dispos. 1995 Jan;23(1):94-101. PubMed PMID: 7720531. 4: Raghavan K, Nemeth G, Gray D, Hussain MA. Stabilization of an anthrapyrazole antitumour agent, DuP 937, on complexation with heptakis(2,6-di-O-methyl)-beta-cyclodextrin in aqueous solution. J Pharm Biomed Anal. 1994 Oct;12(10):1259-64. PubMed PMID: 7841220. 5: Leteurtre F, Kohlhagen G, Paull KD, Pommier Y. Topoisomerase II inhibition and cytotoxicity of the anthrapyrazoles DuP 937 and DuP 941 (Losoxantrone) in the National Cancer Institute preclinical antitumor drug discovery screen. J Natl Cancer Inst. 1994 Aug 17;86(16):1239-44. PubMed PMID: 8040892. 6: Bélanger K, Jolivet J, Maroun J, Stewart D, Grillo-Lopez A, Whitfield L, Wainman N, Eisenhauer E. Phase I pharmacokinetic study of DUP-937, a new anthrapyrazole. Invest New Drugs. 1993 Nov;11(4):301-8. PubMed PMID: 8157472. 7: Shore T, Eisenhauer E, Quirt I, Belanger K, Lohmann R, Silver H, Wielgosz G. A phase II study of DuP 937 (Teloxantrone) in metastatic malignant melanoma: a study of the National Cancer Institute of Canada Clinical Trials Group (NCICCTG). Ann Oncol. 1993 Sep;4(8):695-6. PubMed PMID: 8241003. 8: Gregg RW, Kaizer L, Fine S, Gelmon K, Wielgosz G, Eisenhauer E. A phase II trial of DuP 937 (Teloxantrone) in non-small cell lung cancer. A study of the NCIC Clinical Trials Group. Ann Oncol. 1993 Sep;4(8):693-4. PubMed PMID: 8241002. 9: Maroun JA, Skillings J, MacCormick R, Potvin M, Wielgosz G, Davidson JR, Eisenhauer E. Phase II study on DuP 937 (Teloxantrone) in colorectal carcinoma. A Canadian National Cancer Institute Clinical Trial Group study. Invest New Drugs. 1993 May-Aug;11(2-3):235-7. PubMed PMID: 8262739. 10: Erlichman C, Moore M, Kerr IG, Wong B, Eisenhauer E, Zee B, Whitfield LR. Phase I pharmacokinetic and pharmacodynamic study of a new anthrapyrazole, CI-937 (DUP937). Cancer Res. 1991 Dec 1;51(23 Pt 1):6317-22. PubMed PMID: 1933893. 11: Wong B, Nordblom G, Chang T, Whitfield L. Lack of dose proportional pharmacokinetics for CI-937, an anthrapyrazole DNA intercalator, in mice. Res Commun Chem Pathol Pharmacol. 1989 Nov;66(2):191-202. PubMed PMID: 2602655. 12: Nordblom GD, Pachla LA, Chang T, Whitfield LR, Showalter HD. Development of a radioimmunoassay for the anthrapyrazole chemotherapy agent CI-937 and the pharmacokinetics of CI-937 in rats. Cancer Res. 1989 Oct 1;49(19):5345-51. PubMed PMID: 2766301. 13: Frank P, Novak RF. Effects of anthrapyrazole antineoplastic agents on lipid peroxidation. Biochem Biophys Res Commun. 1986 Nov 14;140(3):797-807. PubMed PMID: 3778486. 14: Reszka K, Kolodziejczyk P, Lown JW. Photosensitization by antitumor agents 2: anthrapyrazole-photosensitized oxidation of ascorbic acid and 3,4-dihydroxyphenylalanine. J Free Radic Biol Med. 1986;2(3):203-11. PubMed PMID: 3033048. 15: Fry DW, Boritzki TJ, Besserer JA, Jackson RC. In vitro DNA strand scission and inhibition of nucleic acid synthesis in L1210 leukemia cells by a new class of DNA complexers, the anthra[1,9-cd]pyrazol-6(2H)-ones (anthrapyrazoles). Biochem Pharmacol. 1985 Oct 1;34(19):3499-508. PubMed PMID: 2413861.

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