Ro 24-4383 | CAS#135312-05-9 | antibacterial agent

MedKoo Cat#: 526177 | Name: Ro 24-4383

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ro 24-4383 is a carbamate-linked dual-action antibacterial agent. Ro 24-4383 is active against 99% of the 363 gram-positive and gram-negative aerobes tested in vitro.

Chemical Structure

Ro 24-4383

CAS#135312-05-9

Theoretical Analysis

MedKoo Cat#: 526177

Name: Ro 24-4383

CAS#: 135312-05-9

Chemical Formula: C32H31FN8O10S2

Exact Mass: 770.1589

Molecular Weight: 770.76

Elemental Analysis: C, 49.87; H, 4.05; F, 2.46; N, 14.54; O, 20.76; S, 8.32

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Ro 24-4383; Ro 244383; Ro 244383.

IUPAC/Chemical Name

(6R,7R)-7-((E)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-(((4-(3-carboxy-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinolin-7-yl)piperazine-1-carbonyl)oxy)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

InChi Key

FPMYMKJOKAOQMT-LJPPBSFJSA-N

InChi Code

InChI=1S/C32H31FN8O10S2/c1-50-37-22(19-13-53-31(34)35-19)26(43)36-23-27(44)41-24(30(47)48)14(12-52-28(23)41)11-51-32(49)39-6-4-38(5-7-39)21-9-20-16(8-18(21)33)25(42)17(29(45)46)10-40(20)15-2-3-15/h8-10,13,15,23,28H,2-7,11-12H2,1H3,(H2,34,35)(H,36,43)(H,45,46)(H,47,48)/b37-22+/t23-,28-/m1/s1

SMILES Code

CO/N=C(\c1csc(n1)N)/C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)COC(=O)N4CCN(CC4)c5cc6c(cc5F)c(=O)c(cn6C7CC7)C(=O)O)C(=O)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 770.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Georgopapadakou NH, Bertasso A. Mechanisms of action of cephalosporin 3'-quinolone esters, carbamates, and tertiary amines in Escherichia coli. Antimicrob Agents Chemother. 1993 Mar;37(3):559-65. PubMed PMID: 8384817; PubMed Central PMCID: PMC187707. 2: Beskid G, Albrecht HA, Fallat V, Keith DD, Lipschitz ER, McGarry CM, McGarry DH, Rossman P, Siebelist J. In vitro and in vivo activity of carbamate-linked dual-action antibacterial Ro 24-4383. Chemotherapy. 1991;37(5):310-7. PubMed PMID: 1804592.