Carbazochrome | Adona | AC-17 | CAS#69-81-8 | Antihemorrhagic Agent

MedKoo Cat#: 329205 | Name: Carbazochrome

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Carbazochrome, also known as Adona and AC-17, is a hemostatic which increases capillary resistance and activates platelet factors.

Chemical Structure

Carbazochrome

CAS#69-81-8

Theoretical Analysis

MedKoo Cat#: 329205

Name: Carbazochrome

CAS#: 69-81-8

Chemical Formula: C10H12N4O3

Exact Mass: 236.0909

Molecular Weight: 236.23

Elemental Analysis: C, 50.84; H, 5.12; N, 23.72; O, 20.32

Price and Availability

Size	Price	Availability	Quantity
5g	USD 250.00	2 Weeks
25g	USD 450.00	2 Weeks

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Related CAS #

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Synonym

Carbazochrome; AC-17; AC 17; AC17; Adona; Adrenochrome Monosemicarbazone; Adrenochrome Semicarbazone; NSC 73742; NSC-73742; NSC-73742;

IUPAC/Chemical Name

(Z)-2-(3-hydroxy-1-methyl-6-oxo-1,2,3,6-tetrahydro-5H-indol-5-ylidene)hydrazine-1-carboxamide

InChi Key

XSXCZNVKFKNLPR-SDQBBNPISA-N

InChi Code

InChI=1S/C10H12N4O3/c1-14-4-9(16)5-2-6(12-13-10(11)17)8(15)3-7(5)14/h2-3,9,16H,4H2,1H3,(H3,11,13,17)/b12-6-

SMILES Code

O=C1/C(C=C2C(O)CN(C)C2=C1)=N\NC(N)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 236.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Oh-oka H, Yamada T, Noto H, Umeyama T, Kadekawa K, Ashitomi K, Nishijima S, Sugaya K. Effect of carbazochrome sodium sulfonate on refractory chronic prostatitis. Int J Urol. 2014 Nov;21(11):1162-6. doi: 10.1111/iju.12533. PubMed PMID: 24964194. 2: Khattab FI, Ramadan NK, Hegazy MA, Al-Ghobashy MA, Ghoniem NS. Validated spectrophotometric methods for simultaneous determination of troxerutin and carbazochrome in dosage form. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Mar 15;139:206-13. doi: 10.1016/j.saa.2014.12.047. PubMed PMID: 25561299. 3: Onodera T, Majima T, Sawaguchi N, Kasahara Y, Ishigaki T, Minami A. Risk of deep venous thrombosis in drain clamping with tranexamic acid and carbazochrome sodium sulfonate hydrate in total knee arthroplasty. J Arthroplasty. 2012 Jan;27(1):105-8. doi: 10.1016/j.arth.2011.02.004. PubMed PMID: 21435821. 4: Hu X, Zheng Y, Wu G, Liu J, Zhu M, Zhou H, Zhai Y, Wu L, Shen-Tu J. Optimization of solid phase extraction clean up and validation of quantitative determination of carbazochrome sodium sulfonate in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Mar 1;951-952:1-6. doi: 10.1016/j.jchromb.2014.01.014. PubMed PMID: 24487058. 5: Song M, Zhao H, Wang L, Yang L, Hang T, Wen A. Development and validation of a robust LC-MS-MS with atmospheric pressure chemical ionization for quantitation of carbazochrome sodium sulfonate in human plasma: application to a pharmacokinetic study. Biomed Chromatogr. 2010 Sep;24(9):990-9. doi: 10.1002/bmc.1397. PubMed PMID: 20146401. 6: Perez-Moreno CI, Couëtil LL, Pratt SM, Ochoa-Acuña HG, Raskin RE, Russell MA. Effect of furosemide and furosemide-carbazochrome combination on exercise-induced pulmonary hemorrhage in Standardbred racehorses. Can Vet J. 2009 Aug;50(8):821-7. PubMed PMID: 19881919; PubMed Central PMCID: PMC2711466. 7: Gan X, Liu S, Liu Z, Hu X, Cui Z, Wang Y. Determination of carbazochrome by fluorescence quenching method. Spectrochim Acta A Mol Biomol Spectrosc. 2012 Nov;97:161-6. doi: 10.1016/j.saa.2012.05.062. PubMed PMID: 22750685. 8: Passali GC, De Corso E, Bastanza G, Di Gennaro L; HHT Gemelli Study Group.. An old drug for a new application: carbazochrome-sodium-sulfonate in HHT. J Clin Pharmacol. 2015 May;55(5):601-2. doi: 10.1002/jcph.452. PubMed PMID: 25644784. 9: Gan XJ, Liu SP, Liu ZF, Hu XL, Tian J, Xue JX. Fluorescence quenching method for the determination of carbazochrome sodium sulfonate with aromatic amino acids. Luminescence. 2013 May-Jun;28(3):265-9. doi: 10.1002/bio.2375. PubMed PMID: 22544487. 10: Sendo T, Itoh Y, Aki K, Oka M, Oishi R. Carbazochrome sodium sulfonate (AC-17) reverses endothelial barrier dysfunction through inhibition of phosphatidylinositol hydrolysis in cultured porcine endothelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2003 Sep;368(3):175-80. PubMed PMID: 12928765. 11: Basile M, Gidaro S, Pacella M, Biffignandi PM, Gidaro GS. Parenteral troxerutin and carbazochrome combination in the treatment of post-hemorrhoidectomy status: a randomized, double-blind, placebo-controlled, phase IV study. Curr Med Res Opin. 2001;17(4):256-61. PubMed PMID: 11922398. 12: Squadrito F, Altavilla D, Oliaro Bosso S. Double-blind, randomized clinical trial of troxerutin-carbazochrome in patients with hemorrhoids. Eur Rev Med Pharmacol Sci. 2000 Jan-Apr;4(1-2):21-4. PubMed PMID: 11409185. 13: Sendo T, Goromaru T, Aki K, Sakai N, Itoh Y, Oishi R. Carbazochrome attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats. Eur J Pharmacol. 2002 Aug 23;450(2):203-8. PubMed PMID: 12206859. 14: Tassniyom S, Vasanawathana S, Dhiensiri T, Nisalak A, Chirawatkul A. Failure of carbazochrome sodium sulfonate (AC-17) to prevent dengue vascular permeability or shock: a randomized, controlled trial. J Pediatr. 1997 Oct;131(4):525-8. PubMed PMID: 9386652. 15: Matsumoto Y, Hayashi T, Hayakawa Y, Shinbo M, Niiya K, Sakuragawa N. Carbazochrome sodium sulphonate (AC-17) decreases the accumulation of tissue-type plasminogen activator in culture medium of human umbilical vein endothelial cells. Blood Coagul Fibrinolysis. 1995 May;6(3):233-8. PubMed PMID: 7654937.