Msh (5-10), cyclic | CAS#137668-62-3 | synthetic peptide

MedKoo Cat#: 597495 | Name: Msh (5-10), cyclic

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Msh (5-10), cyclic is a synthetic peptide tested conjugated with fatty acids for enhanced potency.

Chemical Structure

Msh (5-10), cyclic

CAS#137668-62-3

Theoretical Analysis

MedKoo Cat#: 597495

Name: Msh (5-10), cyclic

CAS#: 137668-62-3

Chemical Formula: C42H56N14O7

Exact Mass: 868.4456

Molecular Weight: 869.00

Elemental Analysis: C, 58.05; H, 6.50; N, 22.57; O, 12.89

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Msh (5-10), cyclic; Cyclic H-asp-his-phe-arg-trp-lys-NH2;

IUPAC/Chemical Name

(2S)-2-((2S,5S,8R,11S,14S)-2-((1H-indol-3-yl)methyl)-11-((4H-imidazol-4-yl)methyl)-14-amino-8-benzyl-5-((E)-3-guanidinoprop-1-en-1-yl)-4,7,10,13,16-pentaoxo-3,6,9,12-tetraazahexadecanamido)-6-aminohexanamide

InChi Key

REPSESXCSAOJCV-BJFGHLDZSA-N

InChi Code

1S/C42H56N14O7/c43-16-7-6-13-31(36(45)58)52-40(62)34(20-26-22-50-30-12-5-4-11-28(26)30)56-38(60)32(14-8-17-49-42(46)47)53-39(61)33(19-25-9-2-1-3-10-25)55-41(63)35(21-27-23-48-24-51-27)54-37(59)29(44)15-18-57/h1-5,8-12,14,18,22-24,27,29,31-35,50H,6-7,13,15-17,19-21,43-44H2,(H2,45,58)(H,52,62)(H,53,61)(H,54,59)(H,55,63)(H,56,60)(H4,46,47,49)/b14-8+/t27?,29-,31-,32-,33+,34-,35-/m0/s1

SMILES Code

O=C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CCCCN)=O)Cc1c2ccccc2[nH]c1)=O)/C=C/CNC(N)=N)[C@H](NC([C@@H](NC([C@@H](N)CC=O)=O)CC3C=NC=N3)=O)Cc4ccccc4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 869.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Shamshirian D, Erfani M, Beiki D, Fallahi B, Shafiei M. Development of a (99m)Tc-labeled lactam bridge-cyclized alpha-MSH derivative peptide as a possible single photon imaging agent for melanoma tumors. Ann Nucl Med. 2015 Oct;29(8):709-20. doi: 10.1007/s12149-015-0998-y. Epub 2015 Jul 8. PubMed PMID: 26152564. 2: Cho MK, Lee CJ, Lee CH, Li SZ, Lim SK, Baik JH, Lee W. Structure and function of the potent cyclic and linear melanocortin analogues. J Struct Biol. 2005 Jun;150(3):300-8. Epub 2005 Apr 13. PubMed PMID: 15890278. 3: Weiss S, Sebben M, Bockaert J. Corticotropin-peptide regulation of intracellular cyclic AMP production in cortical neurons in primary culture. J Neurochem. 1985 Sep;45(3):869-74. PubMed PMID: 2993515. 4: Tammler U, Quillan JM, Lehmann J, Sadée W, Kassack MU. Design, synthesis, and biological evaluation of non-peptidic ligands at the Xenopus laevis skin-melanocortin receptor. Eur J Med Chem. 2003 May;38(5):481-93. PubMed PMID: 12767598. 5: Chartrel N, Tonon MC, Lamacz M, Vaudry H. Adenosine inhibits alpha-melanocyte-stimulating hormone release from frog pituitary melanotrophs. Evidence for the involvement of a(1) adenosine receptors negatively coupled to adenylate cyclase. J Neuroendocrinol. 1992 Dec;4(6):751-7. doi: 10.1111/j.1365-2826.1992.tb00227.x. PubMed PMID: 21554663.